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Large-vessel vasculitis

 

Aneurysms in Takayasu's arteritis: a retrospective study of Chinese patients


1, 2, 3, 4, 5, 6, 7, 8, 9, 10

 

  1. Department of Rheumatology and Immunology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  2. Department of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  3. Department of Vascular Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China.
  4. Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China.
  5. Department of Cardiovascular Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China.
  6. Department of Radiology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  7. Department of Radiology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  8. Department of Rheumatology and Immunology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  9. Department of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  10. Department of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, Shanghai, China. caiqing_2011@126.com

CER12361
2020 Vol.38, N°2 ,Suppl.124
PI 0042, PF 0047
Large-vessel vasculitis

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PMID: 31820727 [PubMed]

Received: 23/04/2019
Accepted : 02/09/2019
In Press: 06/12/2019
Published: 21/05/2020

Abstract

OBJECTIVES:
Aneurysm formation can cause life-threatening complications in Takayasu’s arteritis (TAK). The objective of this study was to evaluate the demographic, clinical and angiographic features, and outcomes of aneurysm secondary to TAK in Chinese patients.
METHODS:
The medical charts of patients diagnosed with TAK in Changhai Hospital between 2001 and 2017 were retrospectively reviewed.
RESULTS:
Aneurysms were identified in 66 (16.6%) of 397 patients with TAK. The mean age at onset was 30.4±11.5 years, with a male:female ratio of 1:2.7. Patients with aneurysm had a higher proportion of male (p<0.01), higher incidences of bruit, chest tightness and aortic regurgitation (all p<0.001), and a lower incidence of visual disturbances (p<0.01) as compared with patients without aneurysm. The prevalence of elevated ESR and CRP and ITAS2010 score were higher in patients with than without aneurysm (all p<0.01). Angiographic classification showed that type V (30.3%) was the most frequent pattern in patients with aneurysm though Type I was dominant in patients without aneurysm. Multiple aneurysms were found in 30.3% of patients and the most common site of aneurysms was abdominal aorta (22.1%). Glucocorticoids were prescribed in 86.4% of patients with aneurysm, and surgical procedures were performed in 80.3%. Five of 52 patients died during the median 3-year follow-up period.
CONCLUSIONS:
These findings could provide useful information on the demographical, clinical and angiographic features of TAK patients with aneurysm. Aneurysm formation in TAK may be associated with male gender and active vascular inflammation.

Rheumatology Article