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Long-term survival of lung transplantation for interstitial lung disease associated with connective tissue diseases: a study of 26 cases from a referral centre


1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12

 

  1. Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.
  2. Pneumology Division, Hospital Universitario Marqués de Valdecilla, Molecular Imaging Group IDIVAL, Santander, Spain.
  3. Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.
  4. Pneumology Division, Hospital Universitario Marqués de Valdecilla, Molecular Imaging Group IDIVAL, Santander, Spain.
  5. Pneumology Division, Hospital Universitario Marqués de Valdecilla, Molecular Imaging Group IDIVAL, Santander, Spain.
  6. Pneumology Division, Hospital Universitario Marqués de Valdecilla, Molecular Imaging Group IDIVAL, Santander, Spain.
  7. Pathology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.
  8. Pneumology Division, Hospital Universitario Marqués de Valdecilla, Molecular Imaging Group IDIVAL, Santander, Spain.
  9. Rheumatology Department, Hospital de la Princesa, IIS-Princesa, Cátedra UAM-Roche (EPID-Future), Universidad Autónoma de Madrid, Madrid, Spain.
  10. Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.
  11. Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués deValdecilla, IDIVAL, Santander; University of Cantabria, School of Medicine, Santander, Spain; and Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. miguelaggay@hotmail.com
  12. Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain. rblanco@humv.es

CER12418
2020 Vol.38, N°4
PI 0615, PF 0620
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PMID: 31694743 [PubMed]

Received: 12/05/2019
Accepted : 22/07/2019
In Press: 17/10/2019
Published: 28/07/2020

Abstract

OBJECTIVES:
Interstitial lung disease (ILD) is a leading cause of mortality in patients with connective tissue diseases (CTD). Lung transplantation has become a viable option for patients with end-stage CTD-ILD. However, patients with CTD are often considered suboptimal candidates for lung transplantation because of concerns of worse outcomes. We assessed post-transplant survival of patients with CTD-ILD compared to patients with idiopathic pulmonary fibrosis (IPF).
METHODS:
Medical records of patients who underwent lung transplantation for CTD-ILD at a single referral centre for lung transplantation in Northern Spain between 1998 and 2018 were reviewed. This cohort was compared with patients with IPF (group-matched for age ±3.3 years, transplant year and use of basiliximab induction previous to transplant). Cumulative survival rates after transplantation were estimated by the Kaplan-Meier method and compared between groups using the log-rank test.
RESULTS:
We studied 26 patients with CTD-ILD and 26 patients with IPF. The underlying diseases of CTD-ILD patients were rheumatoid arthritis (n=9), scleroderma (n=6), Sjögren’s syndrome (n=4), ANCA-associated vasculitis (n=3), anti-synthetase syndrome (n=2), and dermatomyositis, systemic lupus erythematosus (1 each). Baseline characteristics were similar in both groups. CTD-ILD patients experienced acute graft rejection less commonly than those with IPF (32.0% vs. 62.5%; p=0.032). However, a non-statistically significant increased frequency of chronic graft rejection was observed in CTD-ILD patients (20.0% vs. 8.3%; p=0.417). In this regard, the 5-year cumulative survival rates after transplantation was reduced in CTD-ILD (42.4% vs. 65.8%) but the difference did not achieve statistical significance (p=0.075).
CONCLUSIONS:
Long-term post-transplant survival in Northern Spanish patients with CTD-ILD is reduced compared with IPF.

Rheumatology Article