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Recommendations in clinical practice guidelines on gout: systematic review and consistency analysis


1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13

 

  1. Department of Tumour Surgery, Lanzhou University Second Hospital, and The Second Clinical Medical College of Lanzhou University, Lanzhou, China.
  2. The First Clinical Medical College of Lanzhou University, China.
  3. The First Clinical Medical College of Lanzhou University, China.
  4. Department of Endocrine & Rheumatology, Lanzhou General Hospital of Lanzhou Military Area Command of Chinese PLA, Lanzhou, China.
  5. School of Public health, Lanzhou University, China.
  6. The First Clinical Medical College of Lanzhou University, China.
  7. The First Clinical Medical College of Lanzhou University, China.
  8. Department of Tumour Surgery, Lanzhou University Second Hospital, Lanzhou, China.
  9. Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, China.
  10. Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
  11. Institute of Global Health, University of Geneva, and Institute of Mathematical Statistics and Actuarial Science, University of Bern, Switzerland.
  12. Department of Intensive Care Unit, Affiliated Hospital of North Sichuan Medical College, Nanchong, China. qianzc2008@163.com
  13. Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, China. chenyaolong@vip.163.com

CER12449
2020 Vol.38, N°5
PI 0964, PF 0972
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PMID: 31969230 [PubMed]

Received: 26/05/2019
Accepted : 04/11/2019
In Press: 20/01/2020
Published: 02/10/2020

Abstract

OBJECTIVES:
To compare and analyse the recommendations from clinical practice guidelines (CPGs) on gout worldwide, examine the consistency across CPGs, and provide suggestions to develop and update gout guidelines.
METHODS:
We conducted systematic searches in MEDLINE, CBM, GIN, NICE, NGC, WHO, SIGN, DynaMed, UpToDate, and Best Practice databases, from their inception to August 2019 to identify and select CPGs related to gout. We used the search terms “gout”, “hyperuricaemia” and “guideline”. After two rounds of screening, we included the eligible CPGs of gout according to the pre-defined inclusion and exclusion criteria. Methodological quality of included guidelines was assessed with the AGREE-II instrument. The general characteristics of included guidelines and the recommendations were extracted, and the consistency of recommendations across guidelines was compared and analysed.
RESULTS:
A total of 15 gout guidelines including 359 recommendations were retrieved. The main topics covered by the recommendations were diagnosis, pharmacologic treatment of gout flares, pharmacologic urate-lowering therapy (ULT) of chronic gouty arthritis, lifestyle interventions, prophylaxis, and management of asymptomatic hyperuricaemia. The results of AGREE-II appraisal showed that only two guidelines achieved high scores (≥50%) in all six domains. There was substantial discrepancy between the guidelines in recommendations covering the value of computed tomography (CT) and x-rays for diagnosis, the use of corticosteroids as a first-line treatment for flare, the use of colchicine, indications for ULT, the use of febuxostat as first-line ULT, the administration of allopurinol, and the timing of ULT initiation. CONLUSIONS: A number of countries are devoting themselves to the development of gout guidelines, but the process of updating guidelines is slower than that suggested by the WHO. Methodological quality is not satisfactory in most guidelines, and recommendations between guidelines are not consistent.

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