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Thrombocytopenia in idiopathic inflammatory myopathies: a case series analysis

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11

 

  1. Rheumatology Unit (DETO), University of Bari, and Service de Physiologie, Unité d'Explorations Fonctionnelles Musculaires, Hôpitaux Universitaires de Strasbourg, France.
  2. Rheumatology Division, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy, and European Reference Network ReCONNET. silvia.grignaschi@gmail.com
  3. Rheumatology Unit (DETO), University of Bari, Italy.
  4. Rheumatology Division, Hospital G. Pini-CTO, University of Milan, Italy.
  5. Rheumatology Division, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy, and European Reference Network ReCONNET.
  6. Rheumatology Division, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy, and European Reference Network ReCONNET.
  7. Service de Physiologie, Unité d'Explorations Fonctionnelles Musculaires, Hôp.Univ. de Strasbourg, France; European Reference Network ReCONNET, and Centre National de Référence des Maladies Systémiques et Auto-immunes Rares Grand-Est Sud-Ouest (RESO), Service de Rhumatologie, Hôpitaux Universitaires de Strasbourg, France.
  8. Rheumatology Division, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy, and European Reference Network ReCONNET.
  9. Rheumatology Unit (DETO), University of Bari, Italy.
  10. Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Italy.
  11. Rheumatology Division, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy, and European Reference Network ReCONNET.

CER12511
2020 Vol.38, N°5
PI 0891, PF 0895
Full Papers

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PMID: 31820722 [PubMed]

Received: 17/06/2019
Accepted : 01/10/2019
In Press: 09/12/2019
Published: 02/10/2020

Abstract

Idiopathic inflammatory myopathies (IIM) are a group of rare connective tissue diseases (CTDs) deeply affecting patients’ prognosis. Extra-muscular involvement is not rare and skin, joints and lung are the most common targets. However, also dyserythropoiesis has been described, carrying relevant issues on patients’ management and follow-up, as for example, lymphopenia has been associated with an increased risk of rapid progressive interstitial lung disease in anti-MDA5 positive dermatomyositis. Conversely to systemic lupus erythematosus, thrombocytopenia has only been rarely described in IIM and very few authors focused on its potential prognostic implications. We describe five cases of thrombocytopenia in IIM patients positive for myositis specific (MSA) or associated (MAA) autoantibodies. These reports extend the spectrum of haematological features associated to IIM, focusing also on potential risk factors for thrombocytopenia occurrence.

Rheumatology Article