impact factor, citescore
logo
In press
In Press
Recent issue
Recent issue
Recent Supplement
Recent supplement
archives
Archives
articles free
Free to view
Search
Search
 

Reviews

 

The kaleidoscope of neurological manifestations in primary Sjögren’s syndrome

1, 2, 3, 4, 5, 6

 

  1. Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
  2. Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, and Department of Medicine, ASL 1 Avezzano-Sulmona-L’Aquila, Italy.
  3. Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
  4. Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy.
  5. Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy.
  6. Rheumatology Unit, Department of Medicine, University of Perugia, Italy. roberto.gerli@unipg.it

CER12552
2019 Vol.37, N°3 ,Suppl.118
PI 0192, PF 0198
Reviews

Free to view
(click on article PDF icon to read the article)

PMID: 31464676 [PubMed]

Received: 02/07/2019
Accepted : 08/07/2019
In Press: 28/08/2019
Published: 28/08/2019

Abstract

Neurologic involvement is a common extraglandular manifestation of primary Sjögren’s syndrome (pSS), is varied and can be divided anatomically into 3 categories: central nervous system, peripheral neuropathies and autonomous nervous system manifestations. According to different study cohorts, neurological manifestations can occur in 18-45% of pSS patients, with the peripheral nervous system being the most frequent site of involvement compared to the central nervous system and autonomic system. Some neurologic complications share convergent pathophysiology, although the pathological basis of other conditions, namely cognitive impairment in pSS, is less clear. The heterogeneity of neurologic manifestations in pSS complicates the diagnosis and approach to treatment, which should be directed toward the underlying neuro-pathologic mechanism. The diagnosis and treatment of these manifestations must be optimised in order to avoid severe disability. However, for the majority of the complications, evidence for treatment efficacy is limited and requires further investigation.

Rheumatology Article