Diagnosis
Impaired micronutrients and prealbumin in patients with established and very early systemic sclerosis
J. Läubli1, R. Dobrota2, B. Maurer3, S. Jordan4, B. Misselwitz5, M. Fox6, O. Distler7
- Department of Rheumatology, University Hospital Zurich, Switzerland.
- Department of Rheumatology, University Hospital Zurich, Switzerland.
- Department of Rheumatology, University Hospital Zurich, Switzerland.
- Department of Rheumatology, University Hospital Zurich, Switzerland.
- Department of Gastroenterology, University Hospital Zurich, and Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Switzerland.
- Department of Gastroenterology, University Hospital Zurich, and Digestive Function, Basel, Laboratory and Clinic for Motility Disorders and Functional GI Diseases, Centre for Integrative Gastroenterology, Klinik Arlesheim, Switzerland.
- Department of Rheumatology, University Hospital Zurich, Switzerland. oliver.distler@usz.ch
CER12810
2020 Vol.38, N°3 ,Suppl.125
PI 0120, PF 0126
Diagnosis
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PMID: 32828144 [PubMed]
Received: 25/09/2019
Accepted : 16/12/2019
In Press: 29/07/2020
Published: 26/08/2020
Abstract
OBJECTIVES:
Gastrointestinal involvement and impaired nutritional status are frequent in patients with systemic sclerosis (SSc). Hereby, we hypothesised that micronutrients and/or prealbumin could be deficitary in SSc.
METHODS:
Patients with SSc and very early SSc (veSSc) were prospectively included. Clinical assessment, data recording and quality controls followed EUSTAR standards. The UCLA SCTCGIT 2.0 questionnaire was applied and the serum levels of zinc, selenium, prealbumin, holotranscobalamin, folic acid were measured.
RESULTS:
Half (52.4%) of the 176 patients with established SSc showed a deficiency in at least one of the measured nutrients. The most frequent deficit was seen in folic acid (17.9%), followed closely by selenium, prealbumin and zinc (around 15% each). Nearly a fifth (19%) of these patients had multiple deficiencies. Patients with more severe disease, including advanced skin fibrosis, positive ACR 1980 classification criteria, anemia and elevated serum inflammation markers were more likely to be nutrient deficient. Lower BMI<20kg/m2 was associated with several nutrient deficiencies. Prealbumin deficiency was associated with more frequent stomach symptoms and methotrexate therapy. A third of veSSc patients (27%, 44/74) presented a nutrient deficiency, mostly of zinc (10%). Surprisingly, micronutrient deficiencies were not associated with usual parameters of gastrointestinal involvement.
CONCLUSIONS:
These novel data reveal deficiencies in micronutrients and/or prealbumin are a frequent burden in patients with SSc. Moreover, these correlate with clinical aspects of the disease. Especially patients with advanced disease appear at high risk for an impaired nutrient status, suggesting that screening of micronutrients status should be performed in these patients.
