Aetiopathogenesis
Acinar adipose tissue infiltration in salivary gland biopsy is associated with kynurenines-interferon-γ pathway inflammation biomarkers
W.M. Sardenberg1, M.C.L. Santos2, K. Skarstein3, L. Carvalho Caser4, J.G. Brun5, A. Ulvik6, P.M. Ueland7, P.M. Mydel8, R. Jonsson9, V. Valim10
- Hospital Universitário Cassiano Antônio de Moraes, Departamento de Clínica Médica, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, Brazil.
- Hospital Universitário Cassiano Antônio de Moraes, Departamento de Clínica Médica, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, Brazil.
- Gade Laboratorium for Pathology, Department for Clinical Medicine, University of Bergen, Haukeland University Hospital, Bergen, Norway.
- Hospital Universitário Cassiano Antônio de Moraes, Departamento de Clínica Médica, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, Brazil.
- Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Norway.
- Section for Pharmacology, University of Bergen, Norway.
- Section for Pharmacology, University of Bergen, Norway.
- Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Norway.
- Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Norway.
- Hospital Universitário Cassiano Antônio de Moraes, Departamento de Clínica Médica, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, Brazil. val.valim@gmail.com
CER13138
2020 Vol.38, N°4 ,Suppl.126
PI 0027, PF 0033
Aetiopathogenesis
Free to view
(click on article PDF icon to read the article)
PMID: 33095140 [PubMed]
Received: 24/01/2020
Accepted : 22/06/2020
In Press: 22/10/2020
Published: 22/10/2020
Abstract
OBJECTIVES:
Assess if kynurenines metabolites are biomarkers of damage at labial salivary gland biopsy (LSGB).
METHODS:
This is a cross-sectional study including 99 patients with primary Sjögren’s syndrome (AECG 2002 or ACR/EULAR 2017). Kynurenines were measured in plasma using liquid chromatography-tandem mass spectrometry.
RESULTS:
95.9% were females, 51±12 years. Most had focal lymphocytic sialadenitis with focus score ≥1 (73.7%, n=73/99). The majority had mild to severe acinar atrophy (70.4%, n=57/81) and adipose infiltration (51.2%, n=39/80). Individuals with adipose infiltration were older (53.49±12.33 vs. 47.51±11.29 years, p=0.016), showed higher frequency of glandular dysfunction and higher kynurenines levels. Schirmer’s test ≤ 5 mm/5min was found in 69.2% of individuals with adipose infiltration compared to 41% without (p=0.012) and unstimulated whole salivary flow (UWSF) was found in 87.2% compared to 70% without adipose infiltration (p=0.063). Additionally, individuals with adipose infiltration showed higher kynurenines metabolites compared with those without: quinolinic acid (503.35±193.30 vs. 427.35±285.76 nmol/L, p=0.029), kynurenine (1.99±0.6, 54 vs. 1.61±0.46 μmol/L, p=0.006), kynurenine/tryptophan ratio (KTR) (0.030±0.09 vs. 0.025±0.01, p=0.031) and anthranilic acid (03±4.96 vs. 16.46±5.24 nmol/L, p=0.022).
CONCLUSIONS:
Kynurenines are biomarkers of greater adipose infiltration in LSGB and glandular dysfunction suggesting that activation of interferon-γ pathway is involved in the salivary and lacrimal glands damage.