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Tissue factor and human apolipoprotein H genetic variants and pro-inflammatory cytokines in systemic lupus erythematosus patients


1, 2, 3, 4, 5, 6, 7, 8, 9

 

  1. Department of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland. annawajda2046@gmail.com
  2. Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poland.
  3. Department of Connective Tissue, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
  4. Department of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
  5. Department of Connective Tissue, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
  6. Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poland.
  7. Department of Rheumatology and Internal Diseases, Poznan University of Medical Sciences, Poland.
  8. Department of Connective Tissue, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
  9. Department of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.

CER13223
2021 Vol.39, N°3
PI 0587, PF 0600
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PMID: 32896248 [PubMed]

Received: 19/02/2020
Accepted : 01/06/2020
In Press: 03/09/2020
Published: 21/05/2021

Abstract

OBJECTIVES:
Tissue factor (TF) and Human apolipoprotein H (APOH) seem to be significantly associated with a clinical manifestation in systemic lupus erythematosus (SLE) patients with or without APS, mostly because of thrombotic events and coagulation processes. Additionally, according to recent studies, these two factors appear to be an important part of immune response and inflammation.
METHODS:
The objective of this study was to investigate three SNPs of APOH (rs4581, rs8178835 and rs818819) and three of TF (rs958587, rs3917615, rs1361600) in SLE patients and healthy subjects using TaqMan genotyping assay and their association with inflammatory cytokines level in serum and selected clinical parameters.
RESULTS:
Present study revealed that TF rs3917615 and rs958587 and APOH rs4581 possibly predispose to joint involvement in SLE.
CONCLUSIONS:
Analysed genetic variants of TF and APOH may have an impact on inflammatory processes and clinical relevance in SLE patients in the Caucasian population.

Rheumatology Article