One year in review
One year in review 2020: pathogenesis of rheumatoid arthritis
D. Giannini1, M. Antonucci2, F. Petrelli3, S. Bilia4, A. Alunno5, I. Puxeddu6
- Immuno-Allergology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
- Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
- Immuno-Allergology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
- Immuno-Allergology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
- Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
- Immuno-Allergology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy. ilaria.puxeddu@unipi.it
CER13339
2020 Vol.38, N°3
PI 0387, PF 0397
One year in review
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PMID: 32324123 [PubMed]
Received: 18/03/2020
Accepted : 14/04/2020
In Press: 23/04/2020
Published: 26/05/2020
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease influenced by both genetic, epigenetic and environmental factors. The discovery of new gene polymorphisms and their association with disease susceptibility have added new elements to better clarify RA pathogenesis. In the last year, important elements have been added to the current knowledge of mechanisms regulating innate and adaptive immunity in RA, leading to discovering new targets for the development of disease-modifying therapies. Thus, in this review we summarise the new insights resulting from a literature research data published in the last year.
