Full Papers
Evaluation of biomarkers related to endothelial dysfunction: proof of vasculopathy in anti-melanoma differentiation-associated gene 5 dermatomyositis
C. He1, J. Chen2, X. Luo3, B. Yan4
- Department of Rheumatology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
- Department of Rheumatology, People's Hospital of Leshan, Sichuan, China.
- Department of Rheumatology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
- Department of Rheumatology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. yb420@163.com
CER13340
2021 Vol.39, N°1
PI 0151, PF 0157
Full Papers
PMID: 32896243 [PubMed]
Received: 18/03/2020
Accepted : 27/07/2020
In Press: 03/09/2020
Published: 05/02/2021
Abstract
OBJECTIVES:
We aimed to reveal evidence of endothelial dysfunction in the development of anti-melanoma differentiation-associated gene 5 (MDA5) dermatomyositis (DM).
METHODS:
Thirty anti-MDA5 DM patients were enrolled and compared with patients with polymyositis (PM) (n=10) and healthy controls (n=20). The concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), endothelin-1 (ET-1) and von Willebrand factor (vWF) as well as interferon-alpha (IFN-α) and Galcetin-9 in the peripheral blood were tested by enzyme-linked immunosorbent assay (ELISA).
RESULTS:
Plasma levels of sICAM-1, sVCAM-1, ET-1 and vWF were higher in the anti-MDA5 DM patients than in either the healthy controls or the PM patients. In the anti-MDA5 DM cohort, the ET-1 and vWF levels were significantly lower in the cases without cutaneous ulcers and ILD than the other cases. There was a strong positive relationship between the concentrations of ET-1 and Galectin-9 in the anti-MDA5 DM group.
CONCLUSIONS:
Our data suggest that endothelial dysfunction may be involved in the development of anti-MDA5 DM.
