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Review

 

Peripheral neuropathy in mixed cryoglobulinaemia: clinical assessment and therapeutic approach

1, 2, 3, 4, 5, 6, 7, 8, 9

 

  1. Rheumatology Unit, Lupus Clinic M. Scarlato Hospital, Scafati, Italy. poscafati.lupusclinic@aslsalerno.it
  2. Department of Biomedical, Metabolic and Neural Sciences, University of Modena & Reggio Emilia, Modena, Italy.
  3. Rheumatology Unit, Internal Medicine Unit, Presidio Ospedaliero di Saronno, ASST Valleolona, Italy.
  4. Onco-Haematology Unit, CRO Aviano, National Cancer Institute, Aviano, Italy.
  5. Rheumatology Unit, Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Italy.
  6. Unit of Nephrology, ASST degli Spedali Civili di Brescia, Italy.
  7. Rheumatology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  8. Department of Health Sciences, University of Milan, Italy.
  9. Clinica delle Malattie Infettive, L. Sacco Department of Biomedical and Clinical Sciences, University of Milan, Italy.

on behalf of the Italian Group for the Study of Cryoglobulinaemia (GISC)

CER13359
2020 Vol.38, N°6
PI 1231, PF 1237
Review

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PMID: 32573421 [PubMed]

Received: 23/03/2020
Accepted : 20/04/2020
In Press: 23/06/2020
Published: 03/12/2020

Abstract

Peripheral neuropathy (PN) has been detected in up to 69% of patients with mixed cryoglobulinaemic syndrome (MCS). PN should be considered in any patient with sensory and/or motor signs and symptoms in the limbs. Electrodiagnostic tests are mandatory for the diagnosis of PN. Several different sets of diagnostic criteria have been created to assess it. All patients suspected of having neuropathy should undergo a nerve conduction study. A complete neurological evaluation at baseline and periodically should be done possibly by the same neurologists. The authors recommend rigorous scientific evidences that may help to obtain superior tools for accurate diagnosis and management of these conditions. Clinicians, armed with experience and recommendations, can find in this review data-driven guidelines to apply treatments of MCS and closely related disorders.

Rheumatology Article