Clinical aspects
Association of anti-RNA polymerase III antibody with silicone breast implants rupture in a multicentre series of Italian patients with systemic sclerosis
M.G. Lazzaroni1, C. Campochiaro2, E. Bertoldo3, G. De Luca4, C. Caimmi5, A. Tincani6, F. Franceschini7, P. Airò8
- Rheumatology and Clinical Immunology Unit, ASST Spedali Civili of Brescia, and Department of Clinical and Experimental Sciences, University of Brescia, Italy. mariagrazialazzaroni@gmail.com
- Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Hospital and Scientific Institute, Milan, and Vita-Salute San Raffaele University, Milan, Italy.
- Rheumatology Unit, Azienda Ospedaliero Universitaria Integrata, Verona, Italy.
- Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Hospital and Scientific Institute, Milan, and Vita-Salute San Raffaele University, Milan, Italy.
- Rheumatology Unit, Azienda Ospedaliero Universitaria Integrata, Verona, Italy.
- Rheumatology and Clinical Immunology Unit, ASST Spedali Civili of Brescia, and Department of Clinical and Experimental Sciences, University of Brescia, Italy.
- Rheumatology and Clinical Immunology Unit, ASST Spedali Civili of Brescia, and Department of Clinical and Experimental Sciences, University of Brescia, Italy.
- Rheumatology and Clinical Immunology Unit, ASST Spedali Civili of Brescia, Italy.
CER13426
2021 Vol.39, N°4 ,Suppl.131
PI 0025, PF 0028
Clinical aspects
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PMID: 33337991 [PubMed]
Received: 09/04/2020
Accepted : 31/08/2020
In Press: 02/12/2020
Published: 28/07/2021
Abstract
OBJECTIVES:
Systemic sclerosis (SSc) is a heterogeneous systemic autoimmune disease with distinct subsets identified by specific autoantibodies. Some environmental agents might play a role in SSc pathogenesis, including silicone breast implants (SBI). This association has been controversial in previous literature and only few studies reported the auto-antibody status in these SSc women. The objective of this study was to evaluate the association of SBI with SSc in a large cohort of Italian patients, classified according to their SSc-related autoantibodies and to their history of breast cancer.
METHODS:
Three Italian referral centres retrospectively collected clinical and laboratory data of consecutive SSc women, that were included when fulfilling the 2013 ACR/EULAR criteria and when SSc specific auto-antibodies status was available (anti-centromere (ACA), anti-Topoisomerase I (anti-Topo I) and anti-RNA Polymerase III antibodies (anti-RNAP3)). Data regarding history of SBI, SBI rupture and breast cancer were recorded.
RESULTS:
Among 742 SSc women, a history of SBI was recorded in 12 patients (1.6%); in only 1 case the implantation occurred after SSc diagnosis. In SSc patients with anti- RNAP3+ a significantly higher frequency of SBI rupture and SBI rupture without breast cancer were observed, as compared to anti-RNAP3-negative patients. No association was noted for SBI without rupture.
CONCLUSIONS:
In this study we demonstrated a link between SBI rupture and induction of anti-RNAP3+ SSc; further studies are needed to better define the characteristics of this syndrome and the possible effects of SBI removal and immunosuppressive treatment.
