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Intestinal microbiota composition of patients with Behçet's disease: differences between eye, mucocutaneous and vascular involvement. The Rheuma-BIOTA study
N.S. Yasar Bilge1, V. Pérez Brocal2, T. Kasifoglu3, U. Bilge4, N. Kasifoglu5, A. Moya6, E.C. Dinleyici7
- Department of Rheumatology, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey. suleyasar@yahoo.com
- Área de Genómica y Salud, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO-Salud Pública), Valencia, Spain.
- Department of Rheumatology, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
- Department of Family Medicine, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
- Department of Medical Microbiology, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
- Área de Genómica y Salud, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO-Salud Pública), Valencia; Institute for Integrative Systems Biology, Universitat de València, and Spanish Research Council (CSIC), Valencia, and CIBER en Epidemiología y Salud Pública (CIBEResp), Madrid, Spain.
- Department of Paediatrics Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
CER13647
2020 Vol.38, N°5 ,Suppl.127
PI 0060, PF 0068
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PMID: 33124578 [PubMed]
Received: 02/06/2020
Accepted : 21/09/2020
In Press: 16/10/2020
Published: 10/12/2020
Abstract
OBJECTIVES:
Changes in microbiota composition affect the aetiology and patho-genesis of chronic diseases, including Behçet’s disease (BD). However, no studies have analysed the potential gut microbiota changes among different clinical forms of BD. This study evaluated the intestinal microbiota composition of patients with BD and healthy controls and also compared differences between patients with BD with respect to eye, mucocutaneous, and vascular involvement.
METHODS:
In this prospective cohort study, 27 patients diagnosed with BD according to the International Study Group criteria and 10 age- and sex-matched healthy controls were included. Detailed intestinal microbiota analysis was performed.
RESULTS:
There were no differences between the BD group and the control group in terms of alpha and beta microbial diversity and abundance indices (p>0.05). Actinomyces, Libanicoccus, Collinsella, Eggerthella, Enetrohabdus, Catenibacterium, and Enterobacter were significantly higher in the BD group than in the control group. In addition, Bacteroides, Cricetibacter, Alistipes, Lachnospira, Dielma, Akkermansia, Sutterella, Anaerofilum, Ruminococcease-UCG007, Acetanaerobacterium, and Copropaacter were lower in the BD group than in the control group. When we compared three different system involvement (eye, mucocutaneous, and vascular), the linear discriminant analysis effective size revealed a difference for the following genera: Lachnospiraceae NK4A136 in the uveitis group; Dialister, Intestinomonas, and Marvinbryantia in the mucocutaneous group; and Gemella in the vascular group.
CONCLUSIONS:
The composition of intestinal microbiota was significantly different in patients with BD compared with healthy adults. Ours is the first study to show differences in microbiota composition in isolated mucocutaneous, eye, and vascular involvement. These findings should be evaluated in a larger series.
