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Novel approaches for rescuing function of the salivary gland epithelium in primary Sjögren’s syndrome


1, 2, 3, 4, 5

 

  1. Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Centre Groningen, The Netherlands. x.wang@umcg.nl
  2. Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Centre Groningen, the Netherlands.
  3. Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Centre Groningen, the Netherlands.
  4. Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Centre Groningen, the Netherlands.
  5. Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Centre Groningen, the Netherlands.

CER13786
2020 Vol.38, N°4 ,Suppl.126
PI 0261, PF 0270
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PMID: 33095136 [PubMed]

Received: 07/07/2020
Accepted : 27/07/2020
In Press: 23/10/2020
Published: 23/10/2020

Abstract

Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterised by dysfunction and inflammatory lymphocytic infiltration of exocrine glands, namely the salivary and lacrimal glands. pSS patients often suffer from sicca (dry mouth) complaints, including dental caries, and difficulties in eating, sleeping and speaking. A large body of literature points to a central role for salivary gland (SG) epithelial cells in the development of this pathology. Here we summarise recent studies concerning the role of SG epithelial cells in pSS, which strongly indicate their intrinsic activation and early involvement during the disease process. Based on that, we propose possible future interventions targeting SG epithelial cells, to treat SG dysfunction pSS.

Rheumatology Article