Full Papers
Triggering factors for febrile attacks in Japanese patients with familial Mediterranean fever
D. Kishida1, A. Nakamura2, M. Yazaki3, K. Oka4, A. Tsuchiya-Suzuki5, T. Ichikawa6, Y. Shimojima7, Y. Sekijima8
- Department of Medicine (Neurology & Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan. dkishida@shinshu-u.ac.jp
- Department of Medicine (Neurology & Rheumatology), Shinshu University School of Medicine, Matsumoto, and Department of Clinical Research, National Hospital Organization Matsumoto Medical Center, Matsumoto, Japan.
- Institute for Biomedical Sciences, Shinshu University, Matsumoto, and Department of Clinical Laboratory Sciences, Shinshu University School of Health Sciences, Matsumoto, Japan.
- Department of Obstetrics and Gynaecology, Shinshu University, Matsumoto, Japan.
- Department of Medicine (Neurology & Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan.
- Department of Medicine (Neurology & Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan.
- Department of Medicine (Neurology & Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan.
- Department of Medicine (Neurology & Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan.
CER13921
2020 Vol.38, N°5 ,Suppl.127
PI 0076, PF 0079
Full Papers
Free to view
(click on article PDF icon to read the article)
PMID: 33200741 [PubMed]
Received: 11/08/2020
Accepted : 28/10/2020
In Press: 04/11/2020
Published: 10/12/2020
Abstract
OBJECTIVES:
We occasionally encounter patients with familial Mediterranean fever (FMF) whose attacks are triggered by specific factors; however, information regarding these factors is limited. Our purpose was to identify the factors that trigger febrile attacks in Japanese patients with FMF.
METHODS:
Our retrospective study included 372 patients (229 women, 143 men) with FMF, who were diagnosed between April 2007 and June 2018. We retrospectively investigated clinical features, genetic variants, and the factors that the patients perceived to have triggered their attacks. Patients completed a questionnaire that included the following triggering factors, anxiety, psychological stress, tiredness, excitement, environmental change, and menstruation.
RESULTS:
Of 372 patients, 180 (49.4%) reported some triggering factors. Psychological stress and tiredness were commonly reported factors regardless of sex; however, menstruation (39.7%, n=91) was the most commonly reported triggering factor in female patients with FMF. Menstrual-related patients had a younger age of onset and diagnosis, a higher frequency of peritonitis, and a higher rate of patients with endometriosis compared with the non-menstrual-related patients.
CONCLUSIONS:
Gaining an understanding of these triggering factors could help to reduce attacks and educate the patients. Clinicians may need to consider FMF for patients who have fever and serositis that occurs with every menstrual period.
