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Ocular manifestations of Behçet’s disease in children and adults: a systematic review and meta-analysis


1, 2, 3, 4

 

  1. School of Medicine and Medical Science, University College Dublin, Ireland.
  2. University of Toronto, Ontario; Canadian Rheumatology Association Research Studentship, University of Western Ontario, Canada.
  3. Schulich School of Medicine & Dentistry, University of Western Ontario, Division of Rheumatology, St. Joseph’s Health Care, London, Ontario, Canada.
  4. Schulich School of Medicine & Dentistry, University of Western Ontario, Division of Rheumatology, St. Joseph’s Health Care, London, Ontario, Canada. janet.pope@sjhc.london.on.ca

CER13995
2021 Vol.39, N°5 ,Suppl.132
PI 0094, PF 0101
Review

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PMID: 34596037 [PubMed]

Received: 02/09/2020
Accepted : 19/01/2021
In Press: 17/09/2021
Published: 06/10/2021

Abstract

OBJECTIVES:
Children and adults may develop Behçet’s disease (BD), often with ocular involvement such as uveitis. This study aimed to determine the prevalence and type of ocular manifestations in childhood and adult BD.
METHODS:
Medline, Web of Science and Cochrane databases were searched from inception to October 5, 2018 to identify publications related to Behçet’s disease comprising minimum twenty patients and providing the frequency of ocular manifestations (OC). Random effects models were used to combine the prevalence of OC in adults and children with BD. Heterogeneity was evaluated using I2.
RESULTS:
The search resulted in 3129 articles, of which 51 were included in meta-analysis. OCs were slightly more frequent in childhood onset BD with the mean [95% Confidence Interval] frequency of 45 [34-56%] compared to 36 [29-43%] in adults, however, this difference was not statistically significant (p=0.198). In both children and adults, posterior uveitis (children 27% vs. adults 25%, and retinal vasculitis in adults 16%) was the most common ocular manifestation, followed by anterior uveitis (children 18% vs. adults 23%). When comparing the distribution of OC in Behcet’s in adults, there was geographic variation where OC were higher in Turkey and the Middle East 42%, followed by Europe and North America (36%), North Africa 26% and East Asia 25% but not significantly (p=0.27).
CONCLUSIONS:
Ocular manifestations, predominantly uveitis; are common in BD. Ocular manifestations are not proportionately more frequent in adults with BD along the ancient Silk Road.

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