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The elevation of serum uric acid depends on insulin resistance but not fasting plasma glucose in hyperuricaemia


1, 2, 3, 4, 5, 6, 7, 8, 9

 

  1. Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China.
  2. Department of Endocrinology, Suzhou Hospital of Anhui Medical University Suzhou, China.
  3. Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
  4. Jiangsu Provincial Centre for Disease Control and Prevention, Nanjing, China.
  5. School of Public Health, Southeast University, Nanjing, China.
  6. School of Mechanical Engineering, and Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, Southeast University, Nanjing, China.
  7. School of Mechanical Engineering, and Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, Southeast University, Nanjing, China.
  8. Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China. sunzilin1963@126.com
  9. Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, and Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, China. tigershanhu@126.com

CER14423
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PMID: 33886461 [PubMed]

Received: 15/01/2021
Accepted : 29/03/2021
In Press: 15/04/2021

Abstract

OBJECTIVES:
The association between serum uric acid (SUA) and fasting plasma glucose (FPG) has not been fully outlined, in particular in hyperuricaemic population. This study aimed to address this issue, along with the exploration of the role of insulin resistance that was assessed by triglyceride-and-glucose (TyG) index.
METHODS:
A total of 16,297 participants without known diabetes from the SENSIBLE and SENSIBLE-Addition studies were included in the present analysis. Hyperuricaemia was defined as SUA ≥6 mg/dL. Generalised addictive model was applied to establish the relationship of SUA with FPG, and mediation analysis was performed to assess how insulin resistance affected the relationship.
RESULTS:
SUA showed an inverted U-shaped association with FPG, with the turning point of FPG at 6.1 mmol/L and 7.5 mmol/L in normouricaemic and hyperuricaemic participants, respectively. However, the significant relationship between SUA and FPG disappeared in hyperuricaemic participants (form B=3.3, 95% CI: 0.6–5.9, p=0.016 to B= -0.2, 95% CI: -3.1–2.7, p=0.894), and attenuated in normouricaemic participants (from B=9.8, 95% CI: 8.0–11.7, p<0.001 to B=7.3, 95% CI: 5.3–9.2, p<0.001) after controlling for TyG index. In the ascending segment, the relationship between SUA and FPG was partially mediated by TyG index in normouricaemic participants, but fully in hyperuricaemic participants.
CONCLUSIONS:
SUA had an inverted U-shaped relationship with FPG, and their positive relationship was fully mediated by insulin resistance in participants with hyperuricaemia but not those without.

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