impact factor
logo
 

Full Papers

 

Central sensitisation features are associated with neuropathic pain-like symptoms in patients with longstanding rheumatoid arthritis: a cross-sectional study using the central sensitisation inventory


1, 2, 3, 4, 5

 

  1. Division of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
  2. Division of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan, and Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Department of Internal Medicine I, University Hospital Regensburg, Germany. knoda3353@jikei.ac.jp
  3. Division of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
  4. Division of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
  5. Division of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

CER14543
Full Papers

purchase article

PMID: 34128802 [PubMed]

Received: 18/02/2021
Accepted : 03/05/2021
In Press: 08/06/2021

Abstract

OBJECTIVES:
Several studies have indicated that arthralgia may be driven by central sensitisation. Central sensitivity syndrome (CSS) is a concept that unifies various symptoms due to central sensitisation. Recently, the central sensitisation inventory (CSI) was developed as a screening questionnaire to detect CSS. Using the CSI, we examined the prevalence, the clinical characteristics of CSS, and the association between CSS and neuropathic pain (NP)-like symptoms among rheumatoid arthritis (RA) patients.
METHODS:
The CSI was administered to 240 RA outpatients. We evaluated their disease activity and several potentially relevant patient-reported outcomes. We compared the clinical parameters depending on the severity of CSS and examined the effect of the CSI score on NP-like symptoms among the relevant clinical parameters using multivariate analyses.
RESULTS:
The mean disease duration was 9.58 ± 7.76 years. Eighteen (7.5 %) patients had CSS, which was associated with evaluator global assessment (EGA) (odds ratio (OR) 0.860); fibromyalgia symptom scale (OR 1.46); painDETECT questionnaire score (OR 1.24); hospital anxiety and depression scale-anxiety (OR 1.35); and physical (OR 0.898), mental (OR 0.828), and role-social (OR 0.946) component summary scores on the Short-Form 36-Item Health Survey. CSI score was the factor that contributed most to NP-like symptoms (p=0.000, β=0.266).
CONCLUSIONS:
NP-like symptoms might be one of the symptoms of CSS in longstanding RA patients. In longstanding RA patients who have disproportionately greater NP-like symptoms and/or widespread pain compared with degree of inflammation, detecting CSS using CSI might help to understand the pathogenesis of patients.

Rheumatology Article