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Paediatric Rheumatology

 

Children with systemic autoinflammatory diseases have multiple, mixed ethnicities that reflect regional ethnic diversity


1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13

 

  1. Department of Paediatrics, the University of British Columbia, Vancouver, and Division of Rheumatology, British Columbia Children’s Hospital, Vancouver, Canada.
  2. British Columbia Children’s Hospital Research Institute, Vancouver, and Department of Microbiology and Immunology, the University of British Columbia, Vancouver, Canada.
  3. Division of Rheumatology, British Columbia Children’s Hospital, Vancouver, Canada.
  4. Division of Rheumatology, British Columbia Children’s Hospital, Vancouver, Canada.
  5. Division of Rheumatology, British Columbia Children’s Hospital, Vancouver, Canada.
  6. Department of Paediatrics, the University of British Columbia, Vancouver, and Division of Rheumatology, British Columbia Children’s Hospital, Vancouver, Canada.
  7. Department of Paediatrics, the University of British Columbia, Vancouver, and Division of Rheumatology, British Columbia Children’s Hospital, Vancouver, Canada.
  8. Department of Paediatrics, the University of British Columbia, Vancouver, and Division of Rheumatology, British Columbia Children’s Hospital, Vancouver, Canada.
  9. Department of Paediatrics, the University of British Columbia, Vancouver, and Division of Rheumatology, British Columbia Children’s Hospital, Vancouver, Canada.
  10. Department of Paediatrics, the University of British Columbia, Vancouver, and Division of Rheumatology, British Columbia Children’s Hospital, Vancouver, Canada.
  11. Department of Paediatrics, the University of British Columbia, Vancouver, and Division of Rheumatology, British Columbia Children’s Hospital, Vancouver, Canada.
  12. Department of Paediatrics, the University of British Columbia, Vancouver, and British Columbia Children’s Hospital Research Institute, Vancouver, Canada.
  13. Department of Paediatrics, the University of British Columbia, Vancouver; British Columbia Children’s Hospital Research Institute, Vancouver, and Centre for Blood Research, the University of British Columbia, Vancouver, Canada. kbrown@bcchr.ca

CER14653
2021 Vol.39, N°5 ,Suppl.132
PI 0124, PF 0128
Paediatric Rheumatology

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PMID: 34596025 [PubMed]

Received: 23/03/2021
Accepted : 01/09/2021
In Press: 29/09/2021
Published: 06/10/2021

Abstract

OBJECTIVES:
To evaluate the ethnic diversity of children with a systemic autoinflammatory disease (SAID) in a multi-ethnic Canadian province.
METHODS:
Self-reported ethnicity of 149 children and adolescents with a SAID in British Columbia, Canada, was analysed for ethnic representation among individual patients, across the cohort, within particular SAIDs, and compared to provincial census data on ethnic diversity.
RESULTS:
Half of reported cases had a diagnosis of either PFAPA (23.5%) or an unclassifiable autoinflammatory syndrome (31.5%), with a monogenic SAID diagnosed in only 12.8% of cases. The majority of participants (73.1%) were mixed ethnicity with European and Asian heritage reported most frequently (57.0% and 23.0% of all responses, respectively). Ethnic diversity reflected regional diversity except for West Asian, Arabic, Jewish, and Eastern European heritage, which were over-represented in SAID patients, and Chinese descent, which was under-represented in our cohort compared to the general population of British Columbia.
CONCLUSIONS:
Results from this study show extensive multi-ethnic diversity in individual patients and across the various SAIDs inclusive of monogenic SAIDs that are frequently associated with particular ethnicities. Although not disproportionately represented, this is the first report of systemic autoinflammatory disease in Canadian children of Indigenous heritage.

Rheumatology Article

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