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Clinical aspects

 

Respiratory involvement in antineutrophil cytoplasmic antibody-associated vasculitides: a retrospective study based on POLVAS registry

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28

 

  1. 2nd Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland.
  2. Centre for Intensive Care and Perioperative Medicine, Jagiellonian University Medical College, Kraków, Poland.
  3. 2nd Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland.
  4. 2nd Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland.
  5. 2nd Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland.
  6. 2nd Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland.
  7. Department of Internal Medicine, Connective Tissue Diseases and Geriatrics, Medical University of Gdańsk, Poland.
  8. Department of Internal Medicine, Connective Tissue Diseases and Geriatrics, Medical University of Gdańsk, Poland.
  9. Department of Internal Medicine, Connective Tissue Diseases and Geriatrics, Medical University of Gdańsk, Poland.
  10. Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Poland.
  11. Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Poland.
  12. Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wrocław, and Department of Nephrology and Internal Medicine, University of Opole, Poland.
  13. Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wrocław, Poland.
  14. Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wrocław, Poland.
  15. Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wrocław, Poland.
  16. Department of Rheumatology and Internal Diseases, Pomeranian Medical University in Szczecin, Poland.
  17. Department of Rheumatology and Internal Diseases, Pomeranian Medical University in Szczecin, Poland.
  18. Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdańsk, Poland.
  19. Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdańsk, Poland.
  20. Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdańsk, Poland.
  21. Department of Internal Medicine and Rheumatology, Military Institute of Medicine, Warszawa, Poland.
  22. Department of Internal Medicine and Rheumatology, Military Institute of Medicine, Warszawa, and Clinical Research Support Centre, Military Institute of Medicine, Warszawa, Poland.
  23. Department of Internal Diseases and Rheumatology, Central Clinical Hospital of the Ministry of the Interior and Administration, Warszawa, Poland.
  24. Department of Rheumatology and Internal Medicine, Wroclaw Medical University, Wrocław, Poland.
  25. Department of Internal Medicine and Metabolic Diseases, Medical University of Silesia, Katowice, Poland.
  26. Department of Rheumatology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warszawa, Poland.
  27. Department of Internal Medicine, Rheumatology and Clinical Immunology, Medical University of Silesia, Katowice, Poland.
  28. Centre for Intensive Care and Perioperative Medicine, Jagiellonian University Medical College, Kraków, Poland. wojciech.szczeklik@uj.edu.pl

CER14699
2022 Vol.40, N°4
PI 0720, PF 0726
Clinical aspects

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PMID: 35485410 [PubMed]

Received: 06/04/2021
Accepted : 30/08/2021
In Press: 27/04/2022
Published: 04/05/2022

Abstract

OBJECTIVES:
The study aimed to characterise the Polish population of (ANCA)-associated vasculitides (AAV) with respiratory involvement (RI), in comparison to the subgroup without lung manifestations and the other cohorts.
METHODS:
Retrospective analysis of the Polish population of AAV with RI was conducted, based on data from the POLVAS registry. Standard descriptive statistics, χ2 test, and Mann-Whitney U test were used to perform comparisons.
RESULTS:
Among 461 cases qualified to this study, there were 316 cases with RI (68.5%), 206 with granulomatosis with polyangiitis (GPA) (65.2%), 80 with eosinophilic granulomatosis with polyangiitis (EGPA) (25.3%) and 30 with microscopic polyangiitis (MPA) (9.5%). Proportion of RI in GPA, MPA, and EGPA accounted for 67.8%; 40.0%; 97.6%, respectively. The number of relapses was higher in the RI group (median 1.0 vs. 0.0; p=0.01). In the subgroup of combined GPA and MPA with RI, the trends toward higher proportion of deaths (11.7% vs. 5.7%; p=0.07), relapses requiring hospitalisation (52.2% vs. 42.4%, p=0.07) and relapses requiring admission to the intensive care unit (5.6% vs. 1.4%, p=0.09) were observed, median maximal concentration of CRP was higher (46 vs. 25 mg/l; p=0.01) and more aggressive treatment was administered.
CONCLUSIONS:
Prevalence of RI in the Polish population of AAV is similar to the values reported in the literature, however, the proportion observed in GPA is closer to those presented in Asian than Western European cohorts. RI seems to be associated with a more severe course of disease and its presence prompts more aggressive treatment.

DOI: https://doi.org/10.55563/clinexprheumatol/tvtyen

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