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Research progress on the pathogenesis and quality of life of patients with primary Sjögren’s syndrome complicated by depression


1, 2, 3, 4, 5, 6

 

  1. Department of Rheumatology and Immunology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, and Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Chengdu, China.
  2. Department of Rheumatology and Immunology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, and Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Chengdu, China.
  3. Department of Rheumatology and Immunology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, and Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Chengdu, China.
  4. Department of Respiratory and Critical Care Medicine, Chengdu First People’s Hospital, Chengdu, China.
  5. Department of Rheumatology and Immunology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, and Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Chengdu, China.
  6. Department of Rheumatology and Immunology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, and Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Chengdu, China. yi2006liu@163.com

CER14704
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PMID: 34596022 [PubMed]

Received: 10/04/2021
Accepted : 25/06/2021
In Press: 28/09/2021

Abstract

In the past decade, an increasing number of studies have found a relationship between the occurrence and development of depression and autoimmune diseases, and the high prevalence of depression in patients with connective tissue diseases has also been confirmed. Primary Sjögren’s syndrome (pSS) is a chronic autoimmune exocrinopathy characterised by lymphocytic infiltration and exocrine gland destruction. Depression in pSS patients is common, and the factors contributing to this condition are complicated. pSS patients with depression generally have a lower quality of life than pSS patients without depression. Several pathophysiological mechanisms involved in the condition have been proposed in recent years. Thus, in this review, we summarised recent progress on the impact of depression on pSS patients’ quality of life, the possible pathogenesis underlying the development of depression in pSS patients and the management of such patients.

Rheumatology Article