Full Papers

Increased COVID-19 mortality in patients with rheumatic diseases: results from the CONTROL-19 study by the Italian Society for Rheumatology

A. Zanetti¹, G. Carrara², G. Landolfi³, D. Rozza⁴, C.B. Chighizola⁵, A. Alunno⁶, L. Andreoli⁷, R. Caporali⁸, R. Gerli⁹, G.D. Sebastiani¹⁰, G. Valesini¹¹, L. Sinigaglia¹², B. Raffeiner¹³, C. Lomater¹⁴, M. Caprioli¹⁵, M. Fredi¹⁶, N. Romeo¹⁷, G. Cuomo¹⁸, M. Vadacca¹⁹, C.A. Scirè²⁰
Collaborator/s: P. Airò¹, G. Al Khayyat Suhel², C. Alessandri³, E.M. Baldissera⁴, S. Barsotti⁵, F. Bartoli⁶, E. Bartoloni⁷, M. Battellino⁸, C. Bazzani⁹, N. Belai Beyene¹⁰, F. Bellisai¹¹, C. Bellocchi¹², M. Benucci¹³, F. Bergossi¹⁴, D. Bertolucci¹⁵, S. Bettio¹⁶, G. Biasi¹⁷, L. Bonfanti¹⁸, R. Bortolotti¹⁹, A. Bortoluzzi²⁰, N.G. Bucci Romano²¹, S. Bugatti²², F. Campanaro²³, C. Campochiaro²⁴, V. Canti²⁵, A. Cappelli²⁶, D. Carboni²⁷, A. Carletto²⁸, N. Carlo-Stella²⁹, V. Carraro³⁰, L. Castelnovo³¹, I. Cavazzana³², F. Ceccarelli³³, M.S. Chimenti³⁴, E. Cipolletta³⁵, F. Conti³⁶, E. Conticini³⁷, F. Crisafulli³⁸, C. Crotti³⁹, M. Cutolo⁴⁰, R. D’ Alessandro⁴¹, G. Dallagiacoma⁴², M. Dantes⁴³, C. Debilio⁴⁴, M. Di Carlo⁴⁵, F. Dianori⁴⁶, M.C. Ditto⁴⁷, G. Emmi⁴⁸, P. Faggioli⁴⁹, M. Filippini⁵⁰, U. Fiocco⁵¹, F. Franceschini⁵², M. Frassi⁵³, E. Fusaro⁵⁴, A. Gattamelata⁵⁵, M.C. Gerardi⁵⁶, G. Germanò⁵⁷, M. Gerosa⁵⁸, F. Ghellere⁵⁹, R. Giacomelli⁶⁰, S. Giambalvo⁶¹, A. Giollo⁶², R. Gorla⁶³, R. Greco⁶⁴, G. Guidelli⁶⁵, A. Hila⁶⁶, F. Iannone⁶⁷, F. Ingegnoli⁶⁸, A. Iuliano⁶⁹, P. Lazzarin⁷⁰, M.G. Lazzaroni⁷¹, D. Lini⁷², A. Lo Gullo⁷³, M. Longhi⁷⁴, S. Lorusso⁷⁵, A. Lurati⁷⁶, C. Manzo⁷⁷, B. Maranini⁷⁸, C. Mastaglio⁷⁹, L. Moroni⁸⁰, M. Mosca⁸¹, L. Moschetti⁸², C. Nalli Cecilia⁸³, D. Olivo⁸⁴, G. Orsolini⁸⁵, A. Ossandon⁸⁶, V.A. Pacucci⁸⁷, S. Panaro⁸⁸, S. Parisi⁸⁹, S. Piantoni⁹⁰, M. Podswiadek⁹¹, M.G. Portuesi⁹², E. Praino⁹³, P. Prandini⁹⁴, I. Prevete⁹⁵, M. Priora⁹⁶, L. Quartuccio⁹⁷, G.A. Ramirez⁹⁸, R. Reggia⁹⁹, F. Regola¹⁰⁰, V. Riccieri¹⁰¹, M. Riva¹⁰², R. Foti¹⁰³, D. Rossi¹⁰⁴, C. Rotondo¹⁰⁵, D. Sabia¹⁰⁶, F. Saccardo¹⁰⁷, F. Salaffi¹⁰⁸, L. Santo¹⁰⁹, S. Sartorelli¹¹⁰, P. Sarzi Puttini¹¹¹, G. Saviola¹¹², A. Scalvini¹¹³, R. Scarpa¹¹⁴, C. Scirocco¹¹⁵, I. Scotti¹¹⁶, G.D. Sebastiani¹¹⁷, A. Semeraro¹¹⁸, E. Silvagni¹¹⁹, F. Silveri¹²⁰, G. Smerilli¹²¹, F.R. Spinelli¹²², M. Taglietti¹²³, M. Tardella¹²⁴, I. Tinazzi¹²⁵, E. Tirri¹²⁶, M. Todoerti¹²⁷, P. Toniati¹²⁸, E. Treppo¹²⁹, T. Ubiali¹³⁰, A. Vacca¹³¹, V. Varisco¹³², M. Vasile¹³³, S. Vettori¹³⁴, E. Visalli¹³⁵, L. Vultaggio¹³⁶, A. Zabotti¹³⁷, S. Zandonella Callegher¹³⁸, G. Zanframundo¹³⁹, S. Zingarelli¹⁴⁰

Author information

Epidemiology Research Unit, Italian Society for Rheumatology, Milan, and Department of Statistics and Quantitative Methods, Division of Biostatistics, Epidemiology and Public Health, University of Milano-Bicocca, Milan, Italy.
Epidemiology Research Unit, Italian Society for Rheumatology, Milan, Italy.
Epidemiology Research Unit, Italian Society for Rheumatology, Milan, Italy.
Epidemiology Research Unit, Italian Society for Rheumatology, Milan, Italy.
Department of Clinical Sciences and Community Health, Research Center for Adult and Paediatric Rheumatic Diseases, University of Milan, Paediatric Rheumatology Unit, ASST G. Pini and CTO, Milan, Italy.
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
Rheumatology and Clinical Immunology Unit, ASST Spedali Civili, Brescia, and Department of Clinical and Experimental Sciences, University of Brescia, Italy.
Department of Clinical Sciences and Community Health, University of Milan, ASST Pini CTO, Milan, Italy.
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
Rheumatology Unit, Azienda Ospedaliera San Camillo-Forlanini, Roma, Italy.
Rheumatology, Department of Internal Medicine and Medical Specialities, Sapienza University of Rome, Italy.
Past President of the Italian Society for Rheumatology, Italy.
Department of Rheumatology, Central Hospital of Bolzano, Italy.
Rheumatology Unit, Mauriziano Hospital, Turin, Italy.
Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Rheumatology and Clinical Immunology Unit, ASST Spedali Civili, Brescia, and Department of Clinical and Experimental Sciences, University of Brescia, Italy.
Azienda Sanitaria Ospedialiero S. Croce e Carle, Cuneo, Italy.
Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Rheumatology and Immunology Unit, Department of Medicine, University of Rome Campus Bio-Medico, Rome, Italy.
Epidemiology Research Unit, Italian Society for Rheumatology, Milan, and Rheumatology Unit, Department of Medical Sciences, University of Ferrara, Italy. c.scire@reumatologia.it

Collaborator information

ASST Spedali Civili, Brescia, Italy.
Università di Siena, Italy.
UOC Reumatologia Sapienza Università di Roma, Italy.
Unità di Immunologia Reumatologia Immunologia e Malattie Rare Ospedale San Raffaele, Milano, Italy.
Università di Pisa, Italy.
Azienda Ospadaliero-universitaria Careggi, Firenze, Italy.
SC Interaziendale di Reumatologia, Università di Perugia, Italy.
Ospedale S. Antonio - Tolmezzo, Udine, Italy.
ASST Spedali Civili, Brescia, Italy.
P.O.E. Bassini, Milano, Italy.
Uoc Reumatologia Siena, Italy.
Policlinico di Milano, Italy.
Ospedale S.Giovanni di Dio, Firenze, Italy.
Ospedale di Cona, Ferrara, Italy.
Sezione reumatologia Ospedale Versilia, Lucca, Italy.
Medicina 1 - Osp. Ca' Foncello, Treviso, Italy.
Università di Siena, Siena, Italy.
Ufficio Igiene ASL 2 “Marca Trevigiana” regione Veneto, Treviso, Italy.
UO di Reumatologia dell'ospedale S.Chiara, Trento, Italy.
Ospedale di Cona, Ferrara, Italy.
Ssd Reumatologia Ospedaliera Aou "Oo.rr.-Foggia", Foggia, Italy.
Irccs Policlinico San Matteo, Pavia, Italy.
Varese ASST Sette Laghi, Varese, Italy.
IRCCS San Raffaele, Milano, Italy.
IRCCS San Raffaele, Milano, Italy.
ASST Sette Laghi, Varese, Italy.
Azienda Ospadaliero-universitaria Careggi, Firenze, Italy.
UOC Reumatologia AOUI Verona, Italy.
Ospedale di Belluno, Belluno, Italy.
Ospedale SS. Giovanni e Paolo, Venezia, Italy.
ASST Ovest Milanese - Ospedale di Legnano, Milano, Italy.
ASST Spedali Civili, Brescia, Italy.
UOC Reumatologia Sapienza Università di Roma, Roma, Italy.
Ospedale San Camillo, Roma, Italy.
Università Politecnica delle Marche, Ancona, Italy.
UOC Reumatologia Sapienza Università di Roma, Roma, Italy.
Università di Siena, Siena, Italy.
ASST Spedali Civili, Brescia, Italy.
ASST-Gaetano Pini-CTO Milano, Milano, Italy.
U.O.C. Clinica Reumatologica Dipartimento Medicina Interna Ospedale Policlinico San Martino, Genova, Italy.
Università di Siena, Siena, Italy.
Azienda Sanitaria Dell'alto Adige, Bolzano, Italy.
Ospedale San Carlo Borromeo, Milano, Italy
Ambulatorio Po Castelvetrano, Trapani, Italy.
Università Politecnica delle Marche, Ancona, Italy.
Aou Meyer, Firenze, Italy.
Asl Piemonte, Torino, Italy.
Azienda Ospadaliero-universitaria Careggi, Firenze, Italy.
ASST Ovest Milanese - Ospedale di Legnano, Milano, Italy.
ASST Spedali Civili, Brescia, Italy.
Dipartimento di Medicina DIMED Università di Padova, Padova, Italy
ASST Spedali Civili, Brescia, Italy.
ASST Spedali Civili, Brescia, Italy.
Sc Reumatologia Aou Città Della Salute e Della Scienza, Torino, Italy.
Policlinico Umberto I, Roma, Italy.
ASST Ospedale Fatebenefratelli-Sacco, Milano, Italy.
Arcispedale S.Maria Nuova, Reggio Emilia, Italy.
ASST PINI CTO, Milano, Italy.
Castel Goffredo, Mantova, Italy.
Università Campus Bio-Medico, Roma, Italy.
Ospedale di Cona, Ferrara, Italy.
Uoc Reumatologia Aoui, Verona, Italy.
ASST Spedali Civili, Brescia, Italy.
Reumatologia Gavardo - ASST del Garda, Brescia, Italy
Humanitas di Rozzano, Milano, Italy.
Istituto Clinico San Siro, Milano, Italy.
A.O.U.C. Policlinico di Bari, Bari, Italy.
Asst Pini, Milano, Italy.
Uoc Reumatologia Ao San Camillo, Roma, Italy.
Ambulatorio Reumatologia Aulss 6, Padova, Italy.
ASST Spedali Civili, Brescia, Italy.
ASST Spedali Civili, Brescia, Italy.
Asp di Messina, Messina, Italy.
U.O. Reumatologia Istituto Ortopedico Galeazzi, Milano, Italy.
Università Campus Bio-Medico, Roma, Italy.
UOC Reumatologia Magenta ASST Ovest Milanese, Milano, Italy.
Ospedale Pugliese-Ciaccio, Catanzaro, Italy.
Ospedale di Cona, Ferrara, Italy.
Ospedale A Manzoni, Lecco, Italy.
Irccs Ospedale San Raffaele, Milano, Italy.
Università di Pisa, Pisa, Italy.
ASST Spedali Civili, Brescia, Italy.
ASST Spedali Civili, Brescia, Italy.
ASP di Crotone, Crotone, Italy.
Uoc Reumatologia Aoui, Verona, Italy.
Private practice, Roma, Italy.
UOC reumatologia policlinico Umberto I, Roma, Italy
ASST Spedali Civili, Brescia, Italy.
Sc Reumatologia Aou Città Della Salute e Della Scienza, Torino, Italy.
ASST Spedali Civili, Brescia, Italy.
Aulss, Pedemontana, Vicenza, Italy.
ASLTO3 Pinerolo, Torino, Italy.
Uos Di Reumatologia Di Barletta Dss4 Asl Bt, Barletta-Andria-Trani, Italy.
Reumatologia Gavardo - ASST del Garda, Brescia, Italy
San Camillo-Forlanini, Roma, Italy
Asl Cn1 Ospedale Di Mondovì, Cuneo, Italy.
Clinica di Reumatologia di Udine, Udine, Italy.
Irccs Ospedale San Raffaele, Milano, Italy
Ospedale Maggiore di Cremona, Cremona, Italy.
ASST Spedali Civili, Brescia.
Policlinico Umberto I, Roma, Italy.
Ospedale San Gerardo, Monza, Italy.
UO reumatologia AO policlinico San Marco, Catania, Italy.
SS Reumatologia-CMID, Osp G. Bosco - Torino, Torino, Italy.
U.O.C. Reumatologia Universitaria - Policlinico Riuniti di Foggia, Italy.
Caserta, Italy.
Ospedale di Saronno, Varese, Italy
Università Politecnica delle Marche, Ancona, Italy.
Uos Reumatologia Dss4 Barletta - Asl Bt, Barletta-Andria-Trani, Italy.
IRCCS San Raffaele, Milano, Italy.
ASST Ospedale Fatebenefratelli-Sacco, Milano, Italy.
ICS MAUGERI IRCCS- Castel Goffredo, Mantova, Italy.
ASST Spedali Civili, Brescia, Italy.
UOC Reumatologia Federico II, Napoli, Italy.
Azienda Ospedaliera San Camillo Forlanini, Roma, Italy.
ASST-Gaetano Pini-CTO, Milano, Italy.
Uoc Reumatologia Ao San Camillo - Forlanini, Roma, Italy.
Uo Reumatologia Martina Franca, Taranto, Italy.
Ospedale di Cona, Ferrara, Italy.
Università Politecnica delle Marche, Ancona, Italy
Università Politecnica delle Marche, Ancona, Italy
UOC Reumatologia Sapienza Università di Roma, Roma, Italy.
ASST Spedali Civili, Brescia, Italy.
Università Politecnica delle Marche, Ancona, Italy
IRCCS Ospedale Sacro Cuore Negrar, Verona, Italy
UO Reumatologia Ospedale San Giovnni Bosco, Napoli, Italy.
AON di Alessandria, Italy.
ASST Spedali Civili, Brescia, Italy.
Università di Udine, Udine, Italy.
ASST-Gaetano Pini-CTO di Milano, Italy.
S.c. Reumatologia, A.o.u. di Cagliari, Italy.
Ospedale San Gerardo, Monza, Italy.
Ospedale Israelitico, Roma, Italy.
Uoc Malattie, Fisiopatologia, Riabilitazione Respiratoria, Napoli, Italy.
Policlinico Vittorio Emanuele, Catania, Italy.
Ospedale Di Cona, Ferrara, Italy.
Clinica di Reumatologia di Udine, Italy.
Clinica di Reumatologia di Udine, Italy.
Irccs Policlinico San Matteo, Pavia, Italy.
ASST Spedali Civili, Brescia, Italy.

CONTROL-19 study by the Italian Society for Rheumatology

CER14860
2022 Vol.40, N°11
PI 2038, PF 2043
Full Papers

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PMID: 35260224 [PubMed]

Received: 04/06/2021
Accepted : 15/11/2021
In Press: 08/03/2022
Published: 04/11/2022

Abstract

OBJECTIVES:
To investigate differences in coronavirus disease 2019 (COVID-19) mortality between patients with rheumatic musculoskeletal diseases (RMD) and the general population in Italy.
METHODS:
We analysed the data from the national surveillance study promoted by the Italian Society for Rheumatology (CONTROL-19 database) including patients with RMD and COVID-19 between 26 March 2020 and 29 November 2020, compared with official data from the Italian population (within the same period) adjusted for age, sex and geographic location. The main outcome of the analyses was mortality. The relationship between RMD and mortality was analysed using adjusted logistic models and sensitivity analyses were conducted to support the robustness of our results.
RESULTS:
We included 668 RMD patients (62.7% with inflammatory arthritis, 28.6% with systemic autoimmune diseases), who had a mean age of 58.4 years and of which 66% were female. Compared to the general population, the RMD population showed an increased risk of death (OR 3.10 (95% CI 2.29–4.12)), independently from the differences in age and sex distribution. Even after considering the potential influence of surveillance bias, the OR was 2.08 (95% CI: 1.55–2.73). Such excess of risk was more evident in the subgroup of younger patients, and more consistent in women. Subjects with systemic autoimmune diseases showed a higher risk of death than patients with any other RMDs.
CONCLUSIONS:
Patients with RMD and COVID-19 infection evidenced a significant increase in mortality during the first pandemic phases in Italy. These findings support the need for strong SARS-CoV-2 prevention in patients with rheumatic diseases.

DOI: https://doi.org/10.55563/clinexprheumatol/fmyozh