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Concomitant fibromyalgia in primary Sjögren's syndrome in the French ASSESS cohort: comparison of the ACR 1990 and ACR 2016 criteria, FiRST questionnaire and physician's opinion


1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13

 

  1. Department of Rheumatology, University Hospital Gabriel Montpied, Clermont Ferrand, France.
  2. Department of Rheumatology, University Hospital Gabriel Montpied, Clermont Ferrand, France.
  3. Biostatistics Unit, Direction de la Recherche Clinique et de l’Innovation, Clermont Ferrand University Hospital, Clermont Ferrand, France.
  4. Department of Rheumatology, Université Paris-Saclay, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Bicêtre, Centre National de Référence des Maladies Auto-Immunes Rares, INSERM UMR1184, Le Kremlin-Bicêtre, France.
  5. Department of Rheumatology, Université Paris-Saclay, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Bicêtre, Centre National de Référence des Maladies Auto-Immunes Rares, INSERM UMR1184, Le Kremlin-Bicêtre, France.
  6. Department of Rheumatology, Centre National de Référence des Maladies Auto-Immunes Rares, Strasbourg University Hospital, Strasbourg, France.
  7. Department of Internal Medicine, Université Lille, INSERM U1286, Centre de Référence des Maladies Autoimmunes Systémiques Rares du Nord et Nord-Ouest de France (CeRAINO), INFINITE - Institute for Translational Research in Inflammation, Lille, France.
  8. Department of Internal Medicine, Centre de Référence des Maladies Auto-Immunes Rares, Hopital Cochin, APHP, Paris, France.
  9. Department of Rheumatology, CHU Brest, INSERM 1227, Université de Brest, Centre de Référence Maladies Rares CERAINO, LabEx IGO, Brest, France.
  10. Department of Rheumatology, University Hospital Lapeyronie, Montpellier, France.
  11. Department of Rheumatology, Hospital La Source, Orléans, France.
  12. Department of Rheumatology, University Hospital Gabriel Montpied, Clermont Ferrand, France.
  13. Department of Rheumatology, University Hospital Gabriel Montpied, Clermont Ferrand, France. msoubrier@chu-clermontferrand.fr

CER14889
2021 Vol.39, N°6 ,Suppl.133
PI 0140, PF 0145
Clinical aspects

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PMID: 34919043 [PubMed]

Received: 14/06/2021
Accepted : 25/11/2021
In Press: 15/12/2021
Published: 15/12/2021

Abstract

OBJECTIVES:
Dryness, fatigue, and pain are classic symptoms in primary Sjögren’s syndrome (pSS) but are also common in fibromyalgia (FM). We compared the characteristics of FM assessed by different criteria (American College of Rheumatology (ACR) 2016 and 1990 criteria), physician’s opinion and Fibromyalgia Rapid Screening Tool (FiRST) questionnaire) in a cohort of patients with pSS.
METHODS:
Eight hospital departments tested 134 patients with pSS according to AECG criteria from the Assessment of Systemic Signs and Evolution in Sjögren’s Syndrome (ASSESS) cohort. RESUKLTS: FM was present in 19%, 18%, 20%, and 29% of cases according to ACR 2016, ACR 1990 criteria, physician’s opinion and the FiRST questionnaire, respectively. FM criteria-positive patients had higher EULAR SS Patient-Reported Index (ESSPRI) score, but not higher EULAR SS Disease Activity Index (ESSDAI) score. The objective measurements of dryness and the use of corticosteroids and immunosuppressive drugs did not differ between FM positive and negative patients. Regarding the ESSPRI dryness and fatigue subscale scores, depression and anxiety scores and the use of anxiolytics and antidepressants, the FiRST questionnaire exhibited a higher difference between positive and negative patients than ACR 2016 criteria. ACR 1990 and physician’s opinion were somewhere in the middle. ACR 2016 exhibited moderate agreement with ACR 1990 (κ=0.52) and the physician’s opinion (κ=0.60) and poor agreement with FiRST (κ=0.39).
CONCLUSIONS:
The FM criteria identified pSS patients with higher ESSPRI scores but not higher ESSDAI systemic disease scores. Agreement between the different FM criteria was moderate, and the characteristics they described did not fully coincide.

DOI: https://doi.org/10.55563/clinexprheumatol/uxlsh3

Rheumatology Article