Diagnosis
Sonoelastography of salivary glands for diagnosis and clinical evaluation in primary Sjögren’s syndrome
X. Zhang1, S. Zhang2, R. Feng3, H. Yao4, S. Tang5, J. He6
- Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing, China.
- Department of Ultrasound, Peking University People’s Hospital, Beijing, China.
- Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing, China.
- Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing, China.
- Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing, China.
- Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing, China. hejing1105@126.com
CER14941
2021 Vol.39, N°6 ,Suppl.133
PI 0184, PF 0189
Diagnosis
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PMID: 34796854 [PubMed]
Received: 29/06/2021
Accepted : 04/10/2021
In Press: 10/11/2021
Published: 16/12/2021
Abstract
OBJECTIVES:
To explore the performance of sonoelastography (SE) in diagnosis and clinical evaluation of primary Sjögren’s syndrome (pSS).
METHODS:
SE examination of major salivary glands was conducted for 79 pSS patients, 39 disease controls and 15 healthy subjects. Elastographic images were determined with a qualitative 4-point scoring method. Receiver operating characteristic (ROC) curve was employed to evaluate the performance of the elasticity scoring method and the best cut-off value was determined. The associations between elasticity scores and disease characteristics were analysed to evaluate the clinical value of SE for pSS.
RESULTS:
Elasticity scores of parotid and submandibular glands in pSS group were significantly higher than those in the non-pSS group (p<0.001). The sum of the scores of all four glands provided the largest AUC-ROC (0.916, 95% CI 0.87-0.962), compared with that of bilateral parotid glands (0.857, 95% CI 0.794-0.919) and that of bilateral submandibular glands (0.783, 95% CI 0.704-0.863). The optimal cut-off value was 9 for combined evaluation of all four glands (81% sensitivity and 87% specificity, respectively). The elasticity scores of parotid glands in patients with disease duration >10 years experienced significant difference as compared to patients with disease duration ≤5 years and 5-10 years respectively (p=0.007, 0.009, respectively), whereas it presented no variations between the disease duration ≤5 years and 5-10 years (p=0.952).
CONCLUSIONS:
Sonoelastography, performed simultaneously with ultrasonography, is an additional tool for the assessment of the salivary glands in patients with pSS. The elasticity is closely associated with disease duration.
