Clinical aspects
Vascular endothelial growth factor haplotypes are associated with severe ischaemic complications in giant cell arteritis regardless of the disease phenotype
D. Prieto-Peña1, S. Remuzgo-Martínez2, F. Genre3, J.G. Ocejo-Vinyals4, B. Atienza-Mateo5, A. Muñoz-Jimenez6, F. Ortiz-Sanjuán7, S. Romero-Yuste8, C. Moriano9, E. Galíndez-Agirregoikoa10, I. Calvo11, N. Ortego-Centeno12, N. Álvarez-Rivas13, J.A. Miranda-Filloy14, I. Llorente15, R. Blanco16, O. Gualillo17, J. Martín18, A. Márquez19, S. Castañeda20, I. Ferraz-Amaro21, R. López-Mejías22, M.A. González-Gay23
- Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, and Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, Spain.
- Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, Spain.
- Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, Spain.
- Department of Immunology, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
- Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, and Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, Spain.
- Department of Rheumatology, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
- Department of Rheumatology, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
- Department of Rheumatology, Complejo Hospitalario Universitario Pontevedra, Spain.
- Department of Rheumatology, Complejo Asistencial Universitario de León, Spain.
- Department of Rheumatology, Hospital Universitario de Basurto, Bilbao, Spain.
- Department of Rheumatology, Hospital Universitario de Basurto, Bilbao, Spain.
- Autoimmune Diseases Unit, Hospital Universitario San Cecilio, Instituto de Investigación Biosanitaria de Granada (IBS Granada), Department of Internal Medicine, University of Granada, Spain.
- Department of Rheumatology, Hospital Universitario San Agustín, Avilés, Spain.
- Division of Rheumatology, Hospital Universitario Lucus Augusti, Lugo, Spain.
- Department of Rheumatology, Hospital Universitario de la Princesa, IIS-Princesa, Cátedra EPID Future, Universidad Autónoma de Madrid (UAM), Madrid, Spain.
- Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, and Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, Spain.
- Health Research Institute of Santiago, and The NEIRID Group (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Santiago University Clinical Hospital, Santiago de Compostela, Spain.
- Instituto de Parasitología y Biomedicina ‘López-Neyra’, CSIC, PTS Granada, Spain.
- Instituto de Parasitología y Biomedicina ‘López-Neyra’, CSIC, PTS Granada, Spain.
- Department of Rheumatology, Hospital Universitario de la Princesa, IIS-Princesa, Cátedra EPID Future, Universidad Autónoma de Madrid (UAM), Madrid, Spain.
- Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain.
- Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, Spain.
- Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander; Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, and School of Medicine, Universidad de Cantabria, Santander, Spain; and Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. miguelaggay@hotmail.com
CER15002
2022 Vol.40, N°4
PI 0727, PF 0733
Clinical aspects
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PMID: 35349405 [PubMed]
Received: 17/07/2021
Accepted : 04/10/2021
In Press: 23/03/2022
Published: 04/05/2022
Abstract
OBJECTIVES:
To determine whether functional vascular endothelial growth factor (VEGF) polymorphisms influence the expression of the clinical phenotype of giant cell arteritis (GCA). We also evaluated whether VEGF polymorphism is associated with the development of severe ischaemic manifestations in patients with GCA regardless of the clinical phenotype, classic cranial GCA or predominantly extracranial GCA large vessel vasculitis (LVV).
METHODS:
VEGF rs833061 T/C, rs2010963 G/C and rs3025039 C/T polymorphisms were genotyped in 185 patients with biopsy-proven cranial GCA, 105 with extracranial LVV-GCA and 490 healthy controls. Allelic combinations (haplotypes) of VEGF were carried out. Comparisons were performed between patients with GCA and healthy controls as well as between patients with GCA stratified according to the clinical phenotype and the presence of severe ischaemic manifestations.
RESULTS:
No significant differences in genotype, allele, and haplotype frequencies of VEGF were found between patients with GCA and healthy controls as well as between GCA patients with the classic cranial pattern and the extracranial LVV-GCA pattern of the disease. However, the VEGF CGC haplotype (OR= 1.63 [1.05-2.53]) and the CGT haplotype (OR= 2.55 [1.10-5.91]) were significantly more frequent in GCA patients with severe ischaemic complications compared to those patients without these complications.
CONCLUSIONS:
VEGF haplotypes seem to play a role in the development of severe ischaemic manifestations in GCA patients, regardless of the clinical phenotype of expression of the disease.