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Ischaemic heart disease in Behçet's syndrome: a systematic review and meta-analysis
Y. Yang1, Y. Yu2, C. Sun3, M. Jiang4, J. Lin5
- Division of Rheumatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
- Division of Rheumatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
- Division of Rheumatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
- Division of Rheumatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
- Division of Rheumatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. linjinzju@zju.edu.cn
CER15075
2022 Vol.40, N°8
PI 1497, PF 1503
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PMID: 35699061 [PubMed]
Received: 17/08/2021
Accepted : 20/01/2022
In Press: 06/06/2022
Published: 14/09/2022
Abstract
OBJECTIVES:
Behçet’s syndrome (BS) has been reported with cardiovascular involvement. It’s still unclear that BS is associated with the increased risk of ischaemic heart disease (IHD). We aimed to conduct a meta-analysis concerning the incidence of IHD in BS and identify the relationship between IHD and BS.
METHODS:
We performed a comprehensive literature search based on PubMed and Embase databases up to 7 July, 2021. Incidence of IHD was calculated by metaproportion. Pooled risk ratio and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird.
RESULTS:
Four studies with 9237 patients with IHD in BS and 40353 controls were identified and included in our meta-analysis. The pooled risk ratio of IHD in patients with BS was 1.30 and achieved statistical significance (95% CI 1.04-1.64). The statistical heterogeneity was low with an I2 of 39% (p=0.18).
CONCLUSIONS:
In this meta-analysis the presence of BS was associated with an increased risk of IHD. Prospective researches should be done to determine the pathophysiological and prognostic implications of increased IHD in BS.
