Brief Papers
Health-related quality of life in patients with mixed connective tissue disease: a comparison with matched systemic sclerosis patients
I. Abouyahya1, S.I. Liem2, Z. Amoura3, J.E. Fonseca4, B. Chaigne5, M. Cutolo6, A. Doria7, R. Fischer-Betz8, V. Guimaraes9, T.W. Huizinga10, J.M. Van Laar11, T. Martin12, M. Matucci-Cerinic13, C. Montecucco14, M. Schneider15, V. Smith16, U. Müller-Ladner17, J.K. De vries-Bouwstra18
- Department of Rheumatology, Leiden University Medical Center, The Netherlands.
- Department of Rheumatology, Leiden University Medical Center, The Netherlands. s.i.e.liem@lumc.nl
- Service de Médecine Interne, Centre de Référence Maladies Autoimmunes Systémiques Rares d’Ile de France, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP) APHP-CUP, Hôpital Cochin, Université de Paris, France.
- Rheumatology Department, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon Academic Medical Centre, Lisbon, Portugal.
- Service de Médecine Interne, Centre de Référence Maladies Autoimmunes Systémiques Rares d’Ile de France, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP) APHP-CUP, Hôpital Cochin, Université de Paris, France.
- Research Laboratory and Academic Division of Clinical Rheumatology Department of Internal Medicine, IRCCS Polyclinic Hospital San Martino, University of Genoa, Italy.
- Rheumatology Unit Department of Medicine, AO Padova and University of Padova, Italy.
- Department of Rheumatology, University Hospital of Düsseldorf, Germany.
- Liga Portuguesa Contra as Doenças Reumáticas, Lisbon, Portugal.
- Department of Rheumatology, Leiden University Medical Center, The Netherlands.
- Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, The Netherlands.
- Clinical Immunology Department, Hôpitaux Universitaires de Strasbourg, Centre National de Référence des Maladies Systémiques et Auto-immunes Rares Grand-Est Sud-Ouest (RESO), Strasbourg, France.
- Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology, AOUC, Florence, Italy.
- Rheumatology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
- Department of Rheumatology, University Hospital of Düsseldorf, Germany.
- Department of Internal Medicine, Ghent University; Department of Rheumatology, Ghent University Hospital; Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Centre (IRC), Ghent, Belgium.
- Department of Rheumatology and Clinical Immunology, Kerckhoff Klinik, Justus Liebig University of Giessen, Bad Nauheim, Germany.
- Department of Rheumatology, Leiden University Medical Center, The Netherlands.
CER15381
2022 Vol.40, N°5 ,Suppl.134
PI 0066, PF 0070
Brief Papers
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PMID: 35579094 [PubMed]
Received: 29/11/2021
Accepted : 01/04/2022
In Press: 02/05/2022
Published: 18/05/2022
Abstract
OBJECTIVES:
Health-Related Quality of Life (HRQoL) in adult patients with mixed connective tissue disease (MCTD) has not been described so far. Therefore, we performed an explorative study to evaluate HRQoL in MCTD patients.
METHODS:
MCTD patients fulfilling the Kahn criteria and participating in the prospective follow-up cohort for MCTD of the Leiden University Medical Center were included; and matched to systemic sclerosis (SSc) patients based on age, sex and disease duration. Data on disease characteristics and HRQoL (SF36 and EQ-5D) were collected annually. HRQoL was compared between MCTD and SSc patients at baseline. Factors associated with HRQoL in MCTD were identified using linear regression and change in HRQoL over 3 years using linear mixed models.
RESULTS:
Thirty-four MCTD patients (121 visits) and 102 SSc patients (424 visits) were included. At baseline, MCTD patients presented with interstitial lung disease, cardiac involvement, synovitis and myositis more frequently compared to SSc patients, while use of immunosuppressive medication was less frequent. In both groups, mean SF36 scores were lower than in the general Dutch population. The SF36 subscore “general health perception” was impacted most in both groups (MCTD: 38.5 [SD:7.0], SSc: 39.9 [SD:8.9]). During follow-up, SF36 scores improved in MCTD patients, while EQ5DNL remained stable. No specific characteristics were identified that associated with baseline HRQoL or change in HRQol over time.
CONCLUSIONS:
Like in SSc, HRQoL in MCTD is significantly impaired, especially the general health perception of patients. Evaluation in larger prospective cohorts is needed to identify characteristics that impact HRQol most.
