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Candidate autoantibodies for primary Sjögren's syndrome: where are they now?

1, 2, 3


  1. Department of Rheumatology, Concord Repatriation General Hospital, Sydney, and Department of Immunology, Douglass Hanly Moir Pathology, Sonic Health, Macquarie Park, Australia.
  2. Department of Immunology, Blacktown Hospital; School of Medicine, University of Sydney; and Blacktown Clinical School, School of Medicine, Western Sydney University, Australia.
  3. Department of Immunology, Douglass Hanly Moir, Pathology, Sonic Health, Macquarie Park, Australia.

2022 Vol.40, N°12
PI 2387, PF 2394

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PMID: 35616578 [PubMed]

Received: 07/12/2021
Accepted : 14/02/2022
In Press: 26/05/2022
Published: 20/12/2022


Although ANA, SSA and SSB antibody testing are universally accepted biomarkers for Sjögren’s syndrome (SS) diagnosis, they do not occur in all patients. Up to 18% of SS patients are seronegative, with potential for delayed or missed diagnosis. There are no clinically available autoantibodies with predictive value for SS end-organ complications. Over the last three decades, novel autoantibodies for SS diagnosis and monitoring have been identified but few have transitioned from research studies to clinical use. We performed a literature review of candidate serum autoantibodies to examine their persistence in the literature and potential clinical utility. Of the nineteen autoantibodies we identified, AQP5, SP-1, CA6, and PSP Abs have the most promise. Larger cohort studies are needed to determine their potential contribution in SS management.


Rheumatology Article