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Disease activity in patients with rheumatoid arthritis increases serum levels of apolipoprotein C-III

1, 2, 3, 4, 5, 6

 

  1. Division of Internal Medicine, Hospital Universitario de Canarias, Tenerife, and Department of Internal Medicine, University of La Laguna (ULL), Tenerife, Spain.
  2. Division of Endocrinology, Hospital Universitario de Canarias, Tenerife, Spain.
  3. Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Spain.
  4. Division of Health Sciences, Universidad Europea de Canarias, Tenerife, Spain.
  5. Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander; Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain; and Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. miguelaggay@hotmail.com
  6. Department of Internal Medicine, University of La Laguna (ULL), Tenerife, and Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain. iferrazamaro@hotmail.com

CER15410
2023 Vol.41, N°1
PI 0067, PF 0073
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PMID: 35383559 [PubMed]

Received: 12/12/2021
Accepted : 07/03/2022
In Press: 06/04/2022
Published: 23/01/2023

Abstract

OBJECTIVES:
Rheumatoid arthritis (RA) has been unequivocally associated with an increased burden of accelerated atherosclerosis, which, at least in part, is a consequence of the inflammation present in the disease. Apolipoprotein C-III (ApoC3) is a key molecule in triglycerides metabolism that has been linked to cardiovascular (CV) disease. Our objective was to study how ApoC3 is related to the characteristics of RA, paying special attention to its relationship with the inflammatory activity of the disease.
METHODS:
Cross-sectional study that included 430 patients with RA. In these patients, data related to the disease, classic CV risk factors, complete lipid profile, and serum ApoC3 levels were evaluated. A multivariable regression analysis was performed to study the relationship of the characteristics of RA with ApoC3.
RESULTS:
Abdominal circumference, obesity, type 2 diabetes, and circulating triglycerides were significantly associated with higher ApoC3 serum levels. Furthermore, C-reactive protein and erythrocyte sedimentation rate, as well as the disease activity score -DAS28- were significantly related to a higher circulating ApoC3 after multivariable analysis. Patients included in the moderate or high disease activity groups had higher ApoC3 serum levels compared to those in remission (beta coefficient 1.28 [95% confidence interval 0.16-2.39] mg/dl, p=0.025) when adjusting for confounders. The use of prednisone, disease-modifying anti-rheumatic drugs and anti-tumour necrosis factor therapies was associated with lower values of ApoC3.
CONCLUSIONS:
The activity of the disease in patients with RA is independently associated with higher serum levels of ApoC3.

DOI: https://doi.org/10.55563/clinexprheumatol/fe4go6

Rheumatology Article