impact factor, citescore

Full Papers


Toll-like receptor 4 (TLR4) gene polymorphisms in Italian patients with Behçet`s disease

, , , , , , , , , , , , , ,


2009 Vol.27, N°2 ,Suppl.53
PI 0043, PF 0047
Full Papers

Free to view
(click on article PDF icon to read the article)

PMID: 19796532 [PubMed]

Received: 05/02/2009
Accepted : 03/06/2009
In Press: 02/12/2009
Published: 02/12/2009


To investigate potential associations between toll-like receptor 4 (TLR4) gene polymorphisms and susceptibility to, clinical features, and severity of Behçet`s disease (BD).
A total of 189 Italian patients who satisfied the International Study Group criteria for BD and 210 healthy age- and sex-matched blood donors were genotyped for two coding single nucleotide polymorphisms of TLR4 (Asp299Gly and Thr399Ile) by molecular methods. The patients were subgrouped according to the presence or absence of clinical manifestations. Severity score was calculated.
The distribution of allele and genotype frequencies did not differ significantly between the BD patients and the healthy controls. No significant associations were found when BD patients with and those without clinical manifestations were compared. No association between TLR4 polymorphisms and severity score was observed.
Our data suggest that the TLR4 gene polymorphisms are not associated with susceptibility to, clinical expression of, and severity of BD in Italian patients.

Rheumatology Article