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Paediatric Rheumatology

 

SAMHD1 associates with inflammation and vasculitis in paediatric-onset systemic lupus erythematosus

1, 2, 3, 4, 5, 6, 7, 8, 9

 

  1. Department of Rheumatology, National Centre for Children’s Health, Beijing Children’s Hospital, Capital Medical University, Beijing, China.
  2. Department of Rheumatology, National Centre for Children’s Health, Beijing Children’s Hospital, Capital Medical University, Beijing, China. licaifeng123@yeah.net
  3. Department of Rheumatology, National Centre for Children’s Health, Beijing Children’s Hospital, Capital Medical University, Beijing, China.
  4. Department of Rheumatology, National Centre for Children’s Health, Beijing Children’s Hospital, Capital Medical University, Beijing, China.
  5. Department of Rheumatology, National Centre for Children’s Health, Beijing Children’s Hospital, Capital Medical University, Beijing, China.
  6. Department of Rheumatology, National Centre for Children’s Health, Beijing Children’s Hospital, Capital Medical University, Beijing, China.
  7. Department of Rheumatology, National Centre for Children’s Health, Beijing Children’s Hospital, Capital Medical University, Beijing, China.
  8. Department of Rheumatology, National Centre for Children’s Health, Beijing Children’s Hospital, Capital Medical University, Beijing, China.
  9. Department of Rheumatology, National Centre for Children’s Health, Beijing Children’s Hospital, Capital Medical University, Beijing, China.

CER15569
2022 Vol.40, N°9
PI 1801, PF 1807
Paediatric Rheumatology

purchase article

PMID: 35579088 [PubMed]

Received: 09/02/2022
Accepted : 16/04/2022
In Press: 10/05/2022
Published: 20/09/2022

Abstract

OBJECTIVES:
In this study, we aimed to explore the expression of the Aicardi-Goutières syndrome (AGS) mutant gene SAMHD1 in paediatric-onset systemic lupus erythematosus (pSLE), its correlations with clinical and laboratory parameters, and the relationship between its expression and the type 1 interferon (IFN) signalling pathway.
METHODS:
Peripheral blood from 98 pSLE patients and 44 gender and age-matched healthy individuals were examined. Gene expression levels of SAMDH1 and interferon-stimulated genes (ISGs; MxA, IRF3 and IRF7) were evaluated using real-time RT-PCR assays.
RESULTS:
SAMHD1 levels in pSLE patients were significantly increased compared to those in healthy donors (p<0.001). SAMHD1 was associated with serum ferritin (r=0.221, p=0.042) in pSLE patients. SAMHD1 levels were significantly increased (p<0.05) in pSLE patients with butterfly erythema, alopecia, and photosensitivity. SAMHD1 was positively correlated with MxA, IRF3 and IRF7 levels, indicating that SAMHD1 was associated with the type 1 IFN signalling pathway.
CONCLUSIONS:
SAMHD1 was significantly increased and correlated with MxA, IRF3 and IRF7 in pSLE patients.

DOI: https://doi.org/10.55563/clinexprheumatol/4k3gau

Rheumatology Article