One year in review
Pathogenesis of rheumatoid arthritis: one year in review 2022
F. Petrelli1, F.M. Mariani2, A. Alunno3, I. Puxeddu4
- Immuno-Allergology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
- Internal Medicine and Nephrology Unit, Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy.
- Internal Medicine and Nephrology Unit, Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy.
- Immuno-Allergology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy. ilaria.puxeddu@unipi.it
CER15657
2022 Vol.40, N°3
PI 0475, PF 0482
One year in review
Free to view
(click on article PDF icon to read the article)
PMID: 35333708 [PubMed]
Received: 07/03/2022
Accepted : 10/03/2022
In Press: 10/03/2022
Published: 22/03/2022
Abstract
The mechanisms underlying the pathogenesis of rheumatoid arthritis (RA) involve different components of the immune system. In subjects with genetic predisposition to develop RA, a tight interaction between cells and mediators of the innate and adaptive immune system leads to the amplification and perpetuation of inflammation and tissue remodelling. The research carried out in the last year in the field of RA has improved the current knowledge on the pathogenesis of the disease, and is potentially useful to develop new therapeutic approaches. Thus, in this review we provide an overview on the new insights into RA pathogenesis, resulting from a literature search of the data published in the last year.
