Paediatric Rheumatology
Race, ethnicity and patient-reported outcomes in childhood-onset systemic lupus erythematosus
R.E. Borgia1, M.J. Gurka2, S.L. Filipp3, M. Elder4, M. Cardel5, N.J. Shiff6
- Division of Pediatric Allergy, Immunology and Rheumatology, University Hospitals Rainbow Babies & Children’s Hospital, Cleveland, and Department of Health Outcomes and Biomedical Informatics, University of Florida, Gainesville, USA. ezeqborgia@gmail.com
- Department of Pediatrics, University of Florida, Gainesville, USA.
- Department of Pediatrics, University of Florida, Gainesville, USA.
- Division of Pediatric Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Florida, Gainesville, USA.
- Department of Health Outcomes and Biomedical Informatics, University of Florida, Gainesville, USA.
- University of Saskatchewan, Department of Community Health and Epidemiology, Saskatoon, Canada, and Janssen Scientific Affairs, LLC, Horsham, PA, USA.
for the CARRA Registry Investigators
CER15837
2023 Vol.41, N°1
PI 0186, PF 0194
Paediatric Rheumatology
PMID: 36135940 [PubMed]
Received: 10/05/2022
Accepted : 25/07/2022
In Press: 22/09/2022
Published: 23/01/2023
Abstract
OBJECTIVES:
This study assesses the association of race/ethnicity with the Patient-Reported Outcomes Measurement Information System (PROMIS®) in childhood-onset systemic lupus erythematosus (cSLE) patients from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry.
METHODS:
cSLE patients enrolled in the CARRA Registry within two years of cSLE diagnosis who met ACR and/or SLICC classification criteria for lupus were included. Baseline demographics, laboratory, and disease features as well as patient-reported outcomes were obtained. Multivariable linear regression analysis was used to examine the association of race and ethnicity with PROMIS scores at registry enrolment.
RESULTS:
425 cSLE patients met inclusion criteria: 83.8% were female, 30.6% non-Hispanic White, 29.7% Black, 22.1% Hispanic. The mean age at diagnosis was 13.9 years (SD 2.5). Household income and highest parental education varied by race/ethnic group, as did frequency of rash, leukopenia, and anti-Smith antibodies. The cohort had low-moderate baseline disease activity (SLEDAI mean: 6.0 [SD 6.7]). The overall PROMIS Global Health mean T-score was 38.6 (SD 6.5), more than one standard deviation below the general population mean of 50. There was no association between race/ethnicity and PROMIS scores in multivariable linear regression analysis.
CONCLUSIONS:
In this multiethnic paediatric lupus cohort, PROMIS global health was lower when compared with the general paediatric US population. Moreover, PROMIS global health, pain interference, and physical function mobility did not vary across races/ethnicities.
