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Clinical characteristics and predictors for cardiovascular system involvement in patients with Behçet’s disease
Z. Deng1, X. Wang2, T. Li3, C. Lyu4, J. Li5, H. Liu6
- The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China.
- The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China.
- The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong; and Department of Cardiology, Shenzhen Cardiovascular Minimally Invasive Medical Engineering Technology Research and Development Centre, Shenzhen People’s Hospital, The Second Clinical Medical College, The First Affiliated Hospital, Southern University of Science and Technology, Jinan University, Shenzhen, Guangdong, China.
- The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong; and Department of Cardiology, Shenzhen Cardiovascular Minimally Invasive Medical Engineering Technology Research and Development Centre, Shenzhen People’s Hospital, The Second Clinical Medical College, The First Affiliated Hospital, Southern University of Science and Technology, Jinan University, Shenzhen, Guangdong, China.
- Department of Cardiology, Shenzhen Cardiovascular Minimally Invasive Medical Engineering Technology Research and Development Centre, Shenzhen People’s Hospital, The Second Clinical Medical College, The First Affiliated Hospital, Southern University of Science and Technology, Jinan University, Shenzhen, Guangdong, China. 75090935@qq.com
- Department of Cardiology, Shenzhen Cardiovascular Minimally Invasive Medical Engineering Technology Research and Development Centre, Shenzhen People’s Hospital, The Second Clinical Medical College, The First Affiliated Hospital, Southern University of Science and Technology, Jinan University, Shenzhen, Guangdong, China. lhd2578@163.com
CER15920
2023 Vol.41, N°10
PI 1964, PF 1969
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PMID: 36762736 [PubMed]
Received: 04/06/2022
Accepted : 13/10/2022
In Press: 06/02/2023
Published: 30/10/2023
Abstract
OBJECTIVES:
The purpose of this study is to analyse the clinical characteristics of Behçet’s disease (BD) patients in China with or without cardiovascular system involvement, and to develop a risk model to identify factors related to cardiovascular involvement in BD.
METHODS:
This retrospective cohort study, using the information on BD in Shenzhen People’s Hospital from January 2000 to December 2021, included 95 patients: BD patients without cardiovascular system involvement (n=63) and with cardiovascular system involvement (n=32).
RESULTS:
Patients with BD who were males and had a combination of hypertension and a longer duration of disease were more likely to have cardiovascular involvement (p < 0.05). Compared to patients without cardiovascular involvement, manifestations of genital ulcers are rarely observed in those with cardiovascular involvement (60.32% vs. 37.50%, p=0.035). The binary logistic regression analysis found that ascending aortic widening and a history of hypertension were independent risk factors for BD with cardiovascular system involvement (OR=1.277, 95% CI 1.09, 1.495, p=0.002; OR=11.578, 95% CI 1.308, 102.639, p=0.028). The established prediction model indicated that can help to predict the likelihood of cardiovascular involvement in a patient with BD.
CONCLUSIONS:
Cardiovascular involvement in BD is not at all rare, however, it is often underreported due to a lack of specificity. BD patients who are male, have a history of combined hypertension, and have a long duration of disease should be focused on the presence of combined cardiovascular system involvement, with particular attention to the patient’s ascending aortic internal diameter.
