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Patient Acceptable Symptom State (PASS) in patients with primary Sjögren’s syndrome in daily clinical practice
L. De Wolff1, A. Vissink2, J.F. Van Nimwegen3, G. Van Zuiden4, E. Mossel5, L. Olie6, A.J. Stel7, K. Delli8, G.M. Verstappen9, F.G. Kroese10, H. Bootsma11, S. Arends12
- Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Centre Groningen, The Netherlands. l.de.wolff01@umcg.nl
- Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Centre Groningen, the Netherlands.
- Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Centre Groningen, The Netherlands.
- Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Centre Groningen, The Netherlands.
- Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Centre Groningen, The Netherlands.
- Department of Ophthalmology, University of Groningen, University Medical Centre Groningen, the Netherlands.
- Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Centre Groningen, The Netherlands.
- Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Centre Groningen, the Netherlands.
- Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Centre Groningen, The Netherlands.
- Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Centre Groningen, The Netherlands.
- Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Centre Groningen, The Netherlands.
- Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Centre Groningen, The Netherlands.
CER15970
2022 Vol.40, N°12
PI 2303, PF 2309
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PMID: 36441658 [PubMed]
Received: 20/06/2022
Accepted : 26/08/2022
In Press: 28/11/2022
Published: 20/12/2022
Abstract
OBJECTIVES:
To explore Patient Acceptable Symptom State (PASS) in a standard of care cohort of patients with primary Sjögren’s syndrome (pSS) and to compare patient characteristics including EULAR Sjögren’s Syndrome Patient Reported Index (ESSPRI) between PASS and non-PASS groups.
METHODS:
All pSS patients fulfilling ACR/EULAR classification criteria from the Registry of Sjögren’s Syndrome LongiTudinal (RESULT) cohort, who had available PASS data at baseline were included. Patient-reported outcomes included the PASS question: “Considering all the different ways your disease is affecting you, if you were to stay in this state for the next few months, do you consider your current state satisfactory?”; yes: PASS / no: non-PASS.
RESULTS:
Of the 278 included pSS patients, 199 (72%) had an acceptable symptom state according to the PASS question, and median ESSPRI was 6 (IQR 4-7). In the PASS group, 118 (59%) patients had an unacceptable symptom state according to ESSPRI (score ≥5). In multivariable regression analyses, ESSPRI and disease duration were independently associated with presence of PASS. The accuracy of ESSPRI to predict PASS was fair (AUC of 0.78). The cut-off point of ESSPRI for presence of PASS with the highest Youden’s index was 7.2 (sensitivity 85%, specificity 56%), followed by 5.2 (sensitivity 48%, specificity 90%).
CONCLUSIONS:
The majority of pSS patients reported being in an acceptable symptom state according to the PASS question, despite high ESSPRI scores. In our standard of care cohort, the optimal cut-off point of ESSPRI to predict PASS is different when focusing on sensitivity (±7) or specificity (±5).
