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Brief Paper

 

HLA-Cw6 allele and biologic therapy are protective factors against liver fibrosis in psoriatic arthritis patients

1, 2, 3, 4

 

  1. Rheumatology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain. ccmacia@gmail.com
  2. Rheumatology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
  3. Rheumatology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
  4. Rheumatology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.

CER16133
2023 Vol.41, N°5
PI 1179, PF 1182
Brief Paper

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PMID: 36700641 [PubMed]

Received: 14/08/2022
Accepted : 14/11/2022
In Press: 23/01/2023
Published: 03/05/2023

Abstract

OBJECTIVES:
To evaluate the association between liver fibrosis and the HLACw6 allele in psoriatic arthritis (PsA) patients.
METHODS:
A retrospective longitudinal study involving PsA patients with determination of the HLA-Cw6 allele was performed. Liver fibrosis was estimated by using the FIB-4 (fibrosis-4) score. A multivariate logistic model was undertaken to assess the odds ratio (OR), with its 95% confidence interval, of liver fibrosis after adjustment for potential confounding factors.
RESULTS:
A total of 209 PsA patients were included: 25.3% HLA-Cw6 were positive, 59.8% were receiving biological disease-modifying anti-rheumatic drugs (bDMARDs), 29.6% had arterial hypertension (AHT), 24% dyslipidaemia, and 4.2% acute myocardial infarction (AMI). The HLA-Cw6 allele was more frequent in PsA patients with normal FIB-4 values (p=0.024), as opposed to AHT (p=0.002), AMI (p=0.023) and dyslipidaemia (p=0.030), which were found more frequently in subjects with altered FIB-4 values. The presence HLA-Cw6 and the use of bDMARDs were confirmed as protective factors against liver fibrosis (OR 0.210, 0.062–0.707, p=0.012 and OR 0.397, 0.166–0.949, p=0.038, respectively). Conversely, AHT emerged as a risk factor (OR 2.973, 1.125–7.858, p=0.028).
CONCLUSIONS:
In PsA, the HLA-Cw6 allele and bDMARDs behave as protective factors for liver fibrosis, while AHT is an independent risk factor.

DOI: https://doi.org/10.55563/clinexprheumatol/anuuqb

Rheumatology Article