Full Papers
Distinct clinical phenotypes of primary Sjögren’s syndrome differ by onset age: a retrospective study of 742 cases and review of the literature
J. Luo1, Y. Zhang2, J.-Q. Chen3, W.-J. Song4, Q. He5, Z.-W. Huang6, J.-Y. Yang7, Z.-H. Wu8, Y. Xu9, Q.-W. Tao10
- Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, Beijing, and Beijing Key Laboratory of Immune Inflammatory Disease, Beijing, China.
- Graduate School, Beijing University of Chinese Medicine, Beijing, China.
- Graduate School, Beijing University of Chinese Medicine, Beijing, China.
- Traditional Chinese Medicine Department, Peking University Third Hospital, Beijing, China.
- Graduate School, Beijing University of Chinese Medicine, Beijing, China.
- Traditional Chinese Medicine Department, Peking University Third Hospital, Beijing, China.
- Traditional Chinese Medicine Department, Peking University Third Hospital, Beijing, China.
- Traditional Chinese Medicine Department, Peking University Third Hospital, Beijing, China.
- Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, Beijing, and Beijing Key Laboratory of Immune Inflammatory Disease, Beijing, China.
- Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, Beijing, and Beijing Key Laboratory of Immune Inflammatory Disease, Beijing, China. taoqg1@sina.com
CER16210
2022 Vol.40, N°12
PI 2373, PF 2380
Full Papers
Free to view
(click on article PDF icon to read the article)
PMID: 36441650 [PubMed]
Received: 12/09/2022
Accepted : 11/11/2022
In Press: 22/11/2022
Published: 20/12/2022
Abstract
OBJECTIVES:
To study the clinical characteristics of primary Sjögren’s syndrome (pSS) with different onset age, and perform a review of the literature to confirm if the clinical phenotypes are affected by onset age in patients with pSS.
METHODS:
Data of 742 patients with pSS were retrospectively analysed. Patients were divided into three groups according to onset age: young-onset pSS (YopSS, <35 years), adult-onset pSS (AopSS, ≥35 and ≤65 years), and elderly-onset pSS (EopSS, >65 years). Clinical characteristics were compared among three groups and further multiple comparisons were conducted by Bonferroni adjustment. The Chi-squared test for linear-by-linear association was used to explore variation tendency.
RESULTS:
This study included 105 (14.2%), 533 (71.8%), and 104 (14.0%) cases of YopSS, AopSS, and EopSS, respectively. YopSS demonstrated lower prevalence of dry mouth, abnormal Schirmer I tests, and interstitial lung disease (ILD), but higher proportions of low C3 and C4 levels, and ANA, anti-SSA, anti-SSB, and rheumatoid factor (RF) positivity than AopSS and EopSS. The proportions of dry mouth (p=0.004), abnormal Schirmer I tests (p=0.002), and ILD (p<0.001) tended to increase with the increase of onset age, while the prevalence of leukopenia (p=0.011), low C3 (p=0.001), low C4 (p=0.001), and ANA (p<0.001), anti-SSA (p<0.001), anti-SSB (p<0.001) and RF (p<0.001) positivity tended to decrease with an increase in onset age.
CONCLUSIONS:
YopSS demonstrated less dryness and ILD, but more immunologic disorders. ILD prevalence were directly proportional to onset age of pSS; however, leukopenia, hypocomplementaemia, and autoantibody positivity showed opposite trends.
