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Clinical and prognostic features associated with anti-Ro52 autoantibodies in connective tissue diseases patients with interstitial lung disease
X. Shi1, X. Pu2, D. Cao3, T. Yan4, Q. Ye5
- Department of Rheumatology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
- Jiaxing University Master Degree Cultivation Base, Zhejiang Chinese Medical University, Jiaxing, China.
- Department of Respirology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
- Department of Rheumatology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China. candyytt@163.com
- Department of Rheumatology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China. lyjxsh_yq32@163.com
CER16374
2023 Vol.41, N°11
PI 2257, PF 2263
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PMID: 37279146 [PubMed]
Received: 17/11/2022
Accepted : 17/04/2023
In Press: 06/06/2023
Published: 14/11/2023
Abstract
OBJECTIVES:
To define the clinical and prognostic features associated with anti-Ro52 autoantibodies in patients with connective tissue diseases with interstitial lung disease (CTD-ILD).
METHODS:
A total of 238 patients with CTD-ILD were included in this single-centre retrospective cohort study. Patients with positive anti-Ro52 antibodies were selected as the study group, and those with negative anti-Ro52 antibodies were included in the control group. Clinical and follow-up data were analysed.
RESULTS:
Among 238 patients, 145 (60.92%) were positive for the anti-Ro52 antibody. These patients were more likely to have respiratory symptoms at baseline, with more organising pneumonia (OP) patterns and worse forced vital capacity (FVC). Follow-up data were obtained for ILD progression in 170 patients. Varying degrees of progression in pulmonary function (PF) or imaging were found in 48 patients (28.24%) with CTD-ILD. A dichotomous logistic analysis based on the presence or absence of progress showed no correlation with anti-Ro52 antibodies. During the follow-up of 170 patients, there were 35 deaths: 24 in the anti-Ro52 antibody positive group and 11 in the anti-Ro52 antibody negative group. Kaplan-Meier survival curves were used to describe the difference in survival between the two groups (mortality 17.14% vs. 12.5%, log-rank p=0.287). The multivariate logistic analysis showed that ILD progression was associated with older age, worse FVC and diffusion capacity for carbon monoxide at baseline, higher levels of C-reactive protein, serum ferritin, immunoglobulin G and lower absolute lymphocyte count.
CONCLUSIONS:
Anti-Ro52 antibodies may predict more severe lung damage in CTD-ILD; however, anti-Ro52 antibodies were not correlated with progression and death in patients with ILD.
