Full Papers
Impact of disease duration on proteomic bioprofile and prognosis in rheumatoid arthritis patients
M. Brandão1, T. Fonseca2, R. Quelhas Costa3, J.C. Oliveira4, H. Cyrne Carvalho5, P. Rodrigues6, F. Zannad7, P. Rossignol8, M.B. Ferreira9, J.P. Ferreira10
- Unidade Multidisciplinar de Investigação Biomédica, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto; and Unidade de Imunologia Clínica, Centro Hospitalar Universitário do Porto, Portugal. marianabrandao.uic@chporto.min-saude.pt
- Unidade de Imunologia Clínica, Centro Hospitalar Universitário do Porto, Portugal.
- Department of Internal Medicine, Centro Hospitalar de Entre o Douro e Vouga, Aveiro, Portugal.
- Unidade Multidisciplinar de Investigação Biomédica, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto; and Clinical Chemistry Service, Centro Hospitalar de Entre o Douro e Vouga, Aveiro, Portugal.
- Unidade Multidisciplinar de Investigação Biomédica, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto; Cardiology Department Centro Hospitalar Universitário do Porto; and Instituto de Ciências Biomédicas Abel Salazar, Porto, Portugal.
- Unidade Multidisciplinar de Investigação Biomédica, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto; and Cardiology Department Centro Hospitalar Universitário do Porto, Portugal.
- Université de Lorraine, INSERM, Centre d’Investigations Cliniques Plurithématique 1433, CHRU de Nancy, Inserm U1116 F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.
- Université de Lorraine, INSERM, Centre d’Investigations Cliniques Plurithématique 1433, CHRU de Nancy, Inserm U1116 F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France, and Department of Medical Specialties and Nephrology-Haemodialysis, Princess Grace Hospital, Monaco, and Centre d’Hémodialyse Privé de Monaco, Principauté de Monaco.
- Unidade Multidisciplinar de Investigação Biomédica, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto; and Hospital da Luz Arrábida, Porto, Portugal.
- Université de Lorraine, INSERM, Centre d’Investigations Cliniques Plurithématique 1433, CHRU de Nancy, Inserm U1116 F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France, and UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Portugal.
CER16394
2023 Vol.41, N°11
PI 2162, PF 2166
Full Papers
Free to view
(click on article PDF icon to read the article)
PMID: 37470226 [PubMed]
Received: 24/11/2022
Accepted : 20/02/2023
In Press: 13/07/2023
Published: 14/11/2023
Abstract
OBJECTIVES:
Cardiovascular disease worsens the prognosis of rheumatoid arthritis (RA) and vice-versa. Inflammation may be a common pathway for both conditions. It is expected that a longer RA duration leads to a greater inflammatory cumulative exposure burden; however, studies on the association between RA disease duration and outcomes are scarce. Our aim is to compare the characteristics, biomarker expression and outcomes according to the duration of RA.
METHODS:
Prospective cohort study including 399 RA patients, with detailed clinical, echocardiographic, and proteomic phenotyping that were compared across tertiles of RA disease duration. Cox proportional models were used to study the association of disease duration with cardiovascular outcomes.
RESULTS:
RA duration tertiles were: tertile 1 with median of 3.2; tertile 2 with median of 8.8; and tertile 3 with median of 21.8 years. Compared to tertile 1, patients in tertile 3 were older, had more erosive disease, more frequent echocardiographic alterations, lower haemoglobin and walked a shorter distance on the 6MWT. Natriuretic peptides, cathepsin L1, galectin 9, matrix metalloproteinase-12, adrenomedullin and tumour necrosis factor receptor 11A were higher in patients with longer disease duration. Compared to patients in tertile 1, those in tertile 3 had higher risk of a subsequent cardiovascular hospitalisation or cardiovascular death (HR 2.71, 95%CI 1.06-6.92, p=0.04).
CONCLUSIONS:
RA patients with longer disease duration had more organ damage and worse outcomes than those with shorter disease duration. Biomarker expression suggested that patients with longer RA duration had activation of pathways related to inflammation, extracellular matrix organisation, fibrosis and congestion.
