Diagnosis
Comparison of pulmonary and small airways function between idiopathic inflammatory myopathies patients with and without interstitial lung disease
P.K. Panagopoulos1, V.E. Georgakopoulou2, V.C. Pezoulas3, K. Malagari4, D.I. Fotiadis5, A.V. Goules6, T. Vassilakopoulos7, A.G. Tzioufas8
- Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Greece.
- Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Greece.
- Unit of Medical Technology and Intelligent Information Systems, University of Ioannina, Greece.
- 2nd Department of Radiology, University of Athens, Attikon Hospital, Chaidari, Athens, Greece.
- Unit of Medical Technology and Intelligent Information Systems, University of Ioannina, Greece.
- Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Greece.
- Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Greece.
- Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Greece. agtzi@med.uoa.gr
CER16705
2024 Vol.42, N°2
PI 0337, PF 0343
Diagnosis
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PMID: 37382448 [PubMed]
Received: 27/03/2023
Accepted : 12/06/2023
In Press: 28/06/2023
Published: 14/03/2024
Abstract
OBJECTIVES:
To evaluate pulmonary and small airway function in patients with idiopathic inflammatory myopathies (IIM) and make comparisons between patients with and without interstitial lung disease (ILD).
METHODS:
Newly diagnosed IIM patients with and without ILD determined by high resolution computed tomography were included in the study. Pulmonary and small airway function was assessed by spirometry, diffusing capacity for carbon monoxide (DLCO), body plethysmography, single and multiple breath nitrogen washout, impulse oscillometry and measurement of respiratory resistance by the interrupter technique (Rint) using the Q-box system. We used discrepancies between lung volumes measured by multiple breath nitrogen washout and body plethysmography to evaluate for small airway dysfunction.
RESULTS:
Study cohort comprised of 26 IIM patients, 13 with and 13 without ILD. IIM-ILD patients presented more frequently with dyspnoea, fever, arthralgias and positive anti-synthetase antibodies, compared to IIM patients without ILD. Classic spirometric parameters and most lung physiology parameters assessing small airway function did not differ between the two groups. Predicted total lung capacity and residual volume (TLCN2WO, RVN2WO) measured by multiple breath nitrogen washout and the TLCN2WO/TLCpleth ratio were significantly lower in IIM-ILD patients compared to those without ILD (mean: 111.1% vs. 153.4%, p=0.034, median: 171% vs. 210%, p=0.039 and median: 1.28 vs. 1.45, p=0.039, respectively). Rint tended to be higher among IIM-ILD patients (mean:100.5% vs. 76.6%, p=0.053).
CONCLUSIONS:
Discrepancies between lung volumes measured by multiple breath nitrogen washout and body plethysmography in IIM-ILD patients indicate an early small airways dysfunction in these patients.
