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Diagnosis

 

Utility of positron emission tomography as a new tool for muscle involvement in patients with idiopathic inflammatory myositis: a controlled study

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11

 

  1. Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine, University of Istanbul, Turkey.
  2. Department of Nuclear Medicine, Istanbul Faculty of Medicine, University of Istanbul, Turkey.
  3. Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine, University of Istanbul, Turkey.
  4. Department of Internal Medicine, Istanbul Faculty of Medicine, University of Istanbul, Turkey.
  5. Department of Internal Medicine, Istanbul Faculty of Medicine, University of Istanbul, Turkey.
  6. Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine, University of Istanbul, Turkey.
  7. Department of Nuclear Medicine, Istanbul Faculty of Medicine, University of Istanbul, Turkey.
  8. Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine, University of Istanbul, Turkey.
  9. Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine, University of Istanbul, Turkey.
  10. Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine, University of Istanbul, Turkey.
  11. Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine, University of Istanbul, Turkey. drinanc@istanbul.edu.tr

CER16818
2024 Vol.42, N°2
PI 0358, PF 0366
Diagnosis

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PMID: 38293968 [PubMed]

Received: 09/05/2023
Accepted : 25/10/2023
In Press: 29/01/2024
Published: 14/03/2024

Abstract

OBJECTIVES:
Idiopathic inflammatory myositis (IIM) represents a rare group of disease that can affect multiple organs in addition to the muscles. 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is an emerging scanning method that is widely used in diagnosing, staging and response to treatment in patients with cancer. In this study, we aimed to evaluate the muscle involvement in PET/CT which was performed for malignancy screening and its correlation with myositis-specific antibodies (MSA) and/or myositis-associated antibodies (MAA) in patients with IIM.
METHODS:
IIM patients who fulfilled 2017 EULAR/ACR classification criteria and had PET-CT scans during the active phase of myositis (within two weeks of starting steroids) were included into the study. Age and sex matched participants with history of malignancy (non-IIM patients) were defined as control group.
RESULTS:
Data of 160 IIM patients were evaluated and 34 patients (of 64.7% female) whose PET/CT results were available, included into the study. Fourteen patients with diagnosis of malignancy without IIM (non-IIM patients) defined as the control group. Sensitivity and specificity of a positive FDG muscle uptake were 37.1% and 100%, 65.7% and 92.9%, 91.4% and 7.1% compared to liver, mediastinum and LTM uptakes, respectively. In multivariate analysis, higher baseline CRP (p=0.017, confidence interval [CI] 95%: 1.03-1.36, OR:1.18) and LDH (p=0.029, CI 95%:1.001-1.017, OR:1.01) levels were associated with muscle PET/CT positivity.
CONCLUSIONS:
In patients with active IIM, median muscle FDG uptake with PET/CT was higher compared to non-IIM. PET/CT may be used for the evaluation of extent and activity in patients with IIM.

DOI: https://doi.org/10.55563/clinexprheumatol/9u122p

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