impact factor, citescore
logo
In press
In Press
Recent issue
Recent issue
Recent Supplement
Recent supplement
archives
Archives
articles free
Free to view
Search
Search
 

Paediatric Rheumatology

 

Clinical features, treatment and outcomes of Italian children with enthesitis-related arthritis and juvenile psoriatic arthritis: a cross-sectional cohort study

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28

 

  1. UOC Reumatologia e Malattie Infiammatorie, IRCCS Istituto Giannina Gaslini, Genova, Italy.
  2. UOC Reumatologia e Malattie Infiammatorie, IRCCS Istituto Giannina Gaslini, Genova, Italy.
  3. UOC Reumatologia e Malattie Infiammatorie, IRCCS Istituto Giannina Gaslini, Genova, and Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DiNOGMI), Università degli Studi di Genova, Italy.
  4. UOC Reumatologia e Malattie Infiammatorie, IRCCS Istituto Giannina Gaslini, Genova, and Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DiNOGMI), Università degli Studi di Genova, Italy.
  5. UOSD Pediatria a indirizzo reumatologico AOU Policlinico G.Rodolico-San Marco, Catania, Italy.
  6. Clinica Pediatrica e Malattie Rare, Ospedale Microcitemico Antonio Cao, ASL8, Cagliari, Italy.
  7. UOSD Reumatologia e Immunologia Pediatrica, Ospedale Vito Fazzi, Lecce, Italy.
  8. Department of Clinical and Experimental Medicine, University of Pisa, Italy.
  9. Paediatric Rheumatology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy.
  10. Department of Medical of Health Sciences, Magna Graecia University, Catanzaro, Italy.
  11. Divisione di Reumatologia, Istituto Ortopedico Gaetano Pini, Milano, Italy.
  12. UOC Pediatria, Ospedale Pediatrico Giovanni XXIII - Azienda Ospedaliero-Universitaria Consorziale-Policlinico, Bari, Italy.
  13. Department PROMISE G. D’Alessandro, University of Palermo, Italy.
  14. Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.
  15. Paediatric Division, Ospedale Santa Maria della Stella, Ciconia, Orvieto, Italy.
  16. Pediatria, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy.
  17. Immunology and Rheumatology Unit, Regina Margherita Children Hospital, Turin, Italy.
  18. Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
  19. Paediatric Rheumatology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy.
  20. Pediatria C, Ospedale Donna Bambino, Azienda Ospedaliera Universitaria Integrata Verona, Italy.
  21. Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli, Rome, and Università Cattolica Sacro Cuore, Rome, Italy.
  22. Rheumatology Unit, IRCCS Meyer Children’s Hospital, Florence, Italy.
  23. UOC Reumatologia e Malattie Infiammatorie, IRCCS Istituto Giannina Gaslini, Genova, and Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DiNOGMI), Università degli Studi di Genova, Italy.
  24. UOC Reumatologia e Malattie Infiammatorie, IRCCS Istituto Giannina Gaslini, Genova, and Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DiNOGMI), Università degli Studi di Genova, Italy.
  25. IRCCS Istituto Giannina Gaslini, UOC Servizio di Sperimentazioni Cliniche Pediatriche/Gaslini Trial Centre, PRINTO, Genova, Italy.
  26. IRCCS Istituto Giannina Gaslini, UOC Servizio di Sperimentazioni Cliniche Pediatriche/Gaslini Trial Centre, PRINTO, Genova, Italy.
  27. IRCCS Istituto Giannina Gaslini, UOC Servizio di Sperimentazioni Cliniche Pediatriche/Gaslini Trial Centre, PRINTO, Genova, Italy.
  28. UOC Reumatologia e Malattie Infiammatorie, IRCCS Istituto Giannina Gaslini, Genova, and Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DiNOGMI), Università degli Studi di Genova, Italy. alessandroconsolaro@gaslini.org

for the Paediatric Rheumatology International Trials Organisation (PRINTO)

CER16856
2024 Vol.42, N°3
PI 0757, PF 0763
Paediatric Rheumatology

Free to view
(click on article PDF icon to read the article)

PMID: 38147312 [PubMed]

Received: 24/05/2023
Accepted : 28/08/2023
In Press: 22/12/2023
Published: 27/03/2024

Abstract

OBJECTIVES:
Limited information is available on the clinical features, treatment modalities and outcomes of the juvenile idiopathic arthritis (JIA) categories of enthesitis-related arthritis (ERA) and juvenile psoriatic arthritis (JPsA). This study was aimed to describe the characteristics of Italian children with ERA and JPsA and to compare them with those of patients with the other categories of JIA.
METHODS:
Patients were part of a multinational sample included in a study aimed to investigate the prevalence of disease categories, treatment approaches, and disease status in patients from across different geographical areas (EPOCA Study). All patients underwent a retrospective assessment, based on the review of clinical chart, and a cross-sectional evaluation, which included assessment of physician- and parent-reported outcomes and laboratory tests, and recording of ongoing therapies.
RESULTS:
Of the 9081 children with JIA enrolled in the EPOCA Study, 1300 were recruited at 18 paediatric rheumatology centres in Italy. 45 (3.5%) had ERA and 49 (3.8%) had JPsA. Several remarkable differences in demographic features and frequency of articular and extra-articular manifestations, disease damage, impairment in physical function and health-related quality of life, school-related problems, comorbidities, and ongoing treatments were observed between ERA and JPsA and the other JIA categories.
CONCLUSIONS:
We described the characteristics of Italian children with ERA and JPsA and highlighted their peculiarities and their differences from the other JIA subsets. These data provide useful insights for future revisions of JIA classification and a benchmarking against which the features from other cohorts may be compared.

DOI: https://doi.org/10.55563/clinexprheumatol/7xby7y

Rheumatology Article