impact factor, citescore
logo
In press
In Press
Recent issue
Recent issue
Recent Supplement
Recent supplement
archives
Archives
articles free
Free to view
Search
Search
 

Review

 

The effects of mesenchymal stem cells-derived exosomes in rheumatoid arthritis: a review

1, 2, 3, 4, 5, 6, 7, 8

 

  1. Gansu University of Traditional Chinese Medicine, Lanzhou, China.
  2. Gansu University of Traditional Chinese Medicine, Lanzhou, China.
  3. Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, China. 2716633581@qq.com
  4. Fourth Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, China.
  5. Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, China.
  6. Gansu University of Traditional Chinese Medicine, Lanzhou; and Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, China.
  7. Gansu University of Traditional Chinese Medicine, Lanzhou, China.
  8. Gansu University of Traditional Chinese Medicine, Lanzhou, China.

CER16896
2024 Vol.42, N°7
PI 1495, PF 1506
Review

purchase article

PMID: 38019163 [PubMed]

Received: 07/06/2023
Accepted : 04/09/2023
In Press: 23/11/2023
Published: 18/07/2024

Abstract

Rheumatoid arthritis (RA) is a most common chronic joint disease belonging to inflammatory autoimmune disease. The pathology of the disease is characterised by the infiltration and proliferation of fibroblast like synoviocytes (FLSs) and the destruction of the bone and cartilage matrix, which leads to joint dysfunction and even deformity. In recent years, an increasing number of studies have shown that MSCs have immunosuppressive properties and have been demonstrated in a variety of disease. Exosomes serve as carriers that mediate intercellular material transfer and information exchange and contain a variety of biologically active components such as proteins, lipids, and nucleic acids. Mesenchymal stem cell-derived exosomes (MSCs-Exos) play a regulatory role by carrying bioactive substances from the parental cells. Exos-derived from MSCs of different origins can modulate several pathological processes, such as immune inflammatory response, improvement of bone metabolism. In this research, we reviewed the current major pathogenesis of RA and explored the important role of MSCs-Exos in this disease. To be more precise, we summarised the effects of different MSCs-Exos on the pathomechanisms of RA, with a view to providing guidance and reference for future studies.

DOI: https://doi.org/10.55563/clinexprheumatol/l49ccg

Rheumatology Article