Reviews
Insights into the cellular basis of skin inflammation in systemic autoimmune rheumatic diseases from single-cell technologies
K.Y. Su1, C. Roberts2, A.H. Heagerty3, J.A. Reynolds4
- Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, and Rheumatology Department, Sandwell and West Birmingham NHS Trust, Birmingham, UK.
- Department of Cellular Pathology, University Hospitals Birmingham National Health Service Foundation Trust, Birmingham, and Institute of Clinical Sciences, College of Medical & Dental Sciences, University of Birmingham, UK.
- Institute of Inflammation and Ageing, University of Birmingham, and Department of Dermatology, University Hospitals Birmingham National Health Service Foundation Trust, Birmingham, UK.
- Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, and Rheumatology Department, Sandwell and West Birmingham NHS Trust, Birmingham, UK. j.a.reynolds.1@bham.ac.uk
CER17083
2024 Vol.42, N°9
PI 1846, PF 1855
Reviews
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PMID: 39051164 [PubMed]
Received: 24/08/2023
Accepted : 11/03/2024
In Press: 23/07/2024
Published: 23/09/2024
Abstract
Cutaneous inflammation is a common feature of several systemic autoimmune rheumatic diseases (SARDs) including systemic lupus erythematosus (SLE), undifferentiated connective tissue disease (UCTD), mixed connective tissue disease (MCTD) and dermatomyositis (DM) but is less common in other SARDs such as primary Sjögren's syndrome (pSS). It is important to understand whether the pathophysiological processes underlying skin inflammation are different or shared between SARDs to develop targeted therapies. This review will discuss commonalities and differences between inflammatory skin disease in SARDs focusing on histopathology and describe newer insights obtained from single-cell technologies.
