Environmental Rheumatology
Exploring the link between dietary omega-3 and omega-6 fatty acid intake and rheumatoid arthritis risk: NHANES 1999-2020 study
T. Kang1, Y. Xi2, T. Qian3, S. Lu4, M. Du5, X. Shi6, X. Hou7
- Department of Rheumatism, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
- Department of Rheumatism, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
- Department of Rheumatism, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
- Department of Rheumatism, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
- Department of Rheumatism, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
- Department of Rheumatism, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
- Department of Rheumatism, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China. houxiujuan2008@163.com
CER17374
2024 Vol.42, N°9
PI 1720, PF 1728
Environmental Rheumatology
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PMID: 38757295 [PubMed]
Received: 14/12/2023
Accepted : 19/02/2024
In Press: 06/05/2024
Published: 23/09/2024
Abstract
OBJECTIVES:
The association between the ingestion of n-3 and n-6 fatty acids and rheumatoid arthritis (RA) remains unclear. To address this, this study utilised data from the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2020.
METHODS:
Dietary intake information on n-3 and n-6 fatty acids was gathered through 24-hour interviews about dietary recall and adjusted based on weight. RA patient data was collected using questionnaires. Associations were evaluated using logistic regression and spline analyses. The study included a total of 50,352 participants in a cross-sectional manner.
RESULTS:
In the adjusted Model 2, higher odds ratios (ORs) of 0.72 (95% CI: 0.60–0.86) and 0.76 (95% CI: 0.62–0.92) were observed for n-3 and n-6 fatty acid intake, respectively, compared to the lowest category.
CONCLUSIONS:
The results suggest a negative correlation between the ingestion of n-3 and n-6 fatty acids and the risk of rheumatoid arthritis in US adults.