Association of HLA DRB1 alleles with Juvenile Idiopathic Arthritis in Mexicans.

CER209
2010 Vol.28, N°1
PI 0124, PF 0127
Paediatric Rheumatology

Free to view
(click on article PDF icon to read the article)

PMID: 20346252 [PubMed]

Received: 13/02/2009
Accepted : 28/05/2009
In Press: 11/03/2010
Published: 16/03/2010

Abstract

OBJECTIVES:
The aim of the study was to investigate association between HLA class II alleles and juvenile idiopathic arthritis (JIA) in Mexican patients.PATIENTS AND
METHODS:
We typed 120 patients with JIA and 99 healthy controls for HLA class II alleles were performed by PCR-SSO. Differences between the whole group of JIA and its subtypes and controls were calculated by using the &Xgr;²; p-values were corrected (pc) with Bonferroni`s test.
RESULTS:
The alleles HLA-DRB1*01 (pc= 0.00083) and HLA-DRB1*04 (pc=0.0049) were strongly associated with systemic JIA, while HLA-DRB1*11 and HLA-DRB1*14 were found to have decreased frequencies in the patients with systemic JIA compared to the controls. Two alleles were found to have increased frequencies with JIA oligoarthritis subgroup, HLA-DRB1*11 (p=0.01, pc=NS) and HLA-DRB1*13 (p=0.01, pc=NS). The HLA-DRB1*04 was found increased frequencies with susceptibility for RF negative and RF positive polyarthritis JIA subgroups (p correction resulted in loss of significance). In contrast two alleles HLA-DRB1*07 and HLA-DRB1*14 were found decreased frequencies only patients RF positive polyarthritis JIA subgroup compared to the controls (pc=NS).
CONCLUSIONS:
The profile of HLA-DRB1 alleles associations in Mexican with JIA were somewhat distinct from association typically found in Caucasians.