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Environmental Rheumatology

 

Environment and systemic lupus erythematosus

1, 2, 3, 4, 5, 6, 7, 8

 

  1. Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, and Department of Medical Biotechnologies, University of Siena, Italy.
  2. Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, and Department of Medical Biotechnologies, University of Siena, Italy.
  3. Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
  4. Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
  5. Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
  6. Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
  7. Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
  8. Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy. chiara.tani@unipi.it

CER17616
2024 Vol.42, N°5
PI 1104, PF 1114
Environmental Rheumatology

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PMID: 38743446 [PubMed]

Received: 29/02/2024
Accepted : 22/04/2024
In Press: 14/05/2024
Published: 14/05/2024

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of clinical manifestations and a relapsing-remitting course. SLE pathogenesis is the result of complex interactions between ethnic, genetic, epigenetic, immunoregulatory, hormonal and environmental factors, and several aspects of these multifactorial connections are still unclear. Overall, for the disease development, an environmental trigger may induce immunological dysfunction in genetically predisposed individuals. This review aims to summarise the most relevant data on the impact of environmental factors on the incidence of SLE and on disease activity and damage in patients with an established diagnosis of SLE.

DOI: https://doi.org/10.55563/clinexprheumatol/17vmqc

Rheumatology Article