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Effect of fibromyalgia on demographic, biochemical, metabolic and inflammatory profiles: a single-centre retrospective study

1, 2, 3, 4, 5, 6


  1. Department of Rheumatology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
  2. Department of Internal Medicine, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
  3. Department of Endocrinology and Metabolism, Erzurum Regional Training and Research Hospital, Erzurum, Turkey.
  4. University of Montenegro-Faculty of Medicine, Podgorica, and Centre for Laboratory Diagnostics, Primary Health Care Centre, Podgorica, Montenegro.
  5. Department of Endocrinology and Metabolism, Sivas Numune Hospital, Sivas, Turkey.
  6. Department of Endocrinology and Metabolism, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.

2024 Vol.42, N°6
PI 1205, PF 1214
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PMID: 38910579 [PubMed]

Received: 01/04/2024
Accepted : 27/05/2024
In Press: 20/06/2024
Published: 04/07/2024


The objective of this study is to ascertain the disparities in demographic features and biochemical profiles between individuals diagnosed with fibromyalgia (FM) and a control group of healthy individuals.
This retrospective, cross-sectional study compared the demographic, biochemical, metabolic, and inflammatory indexes and rates of 174 FM patients diagnosed using the American College of Rheumatology 2016 diagnostic criteria between January 2023 and January 2024, and 186 healthy control groups.
There was no difference between the FM and control groups in terms of alcohol consumption, marital status, or diabetes mellitus. The smoking rate is higher, and the educational level was found to be lower for FM versus the control. There was no significant difference between FM and controls regarding waist-height ratio, triglyceride-glucose index, plasma atherogenic index, vitamin B12, and folate levels. Monocyte HDL ratio, cardiometabolic index, magnesium, HbA1c, and ferritin levels were significantly higher in the control than in FM (p<0.001, p=0.039, p=0.007, p<0.001, p<0.001, respectively). C-reactive protein, erythrocyte sedimentation rate, systemic immune-inflammatory index, neutrophil-lymphocyte rate, platelet lymphocyte rate, and vitamin D levels were found to be higher in FM compared to control (p=0.001, p=0.032, p=0.003, p=0.030, p=0.003, p<0.001, respectively). A weak positive correlation was observed between the fibromyalgia impact questionnaire (FIQ) score and disease duration, as well as between pain degree and ESR, and pain degree and CRP. The study revealed a weak inverse relationship between Widespread Pain Index (WPI) and waist circumference.
This study highlights fthe association f ibromyalgia with elevated inflammatory markers, altered metabolic parameters, and specific demographic characteristics.


Rheumatology Article