Reviews
The association between rheumatoid arthritis and left ventricular diastolic dysfunction: pathogenesis, predictors and managements
Y. Qian1, B. Zhang2, F. Nian3
- Department of Cardiology, The First Hospital of Jiaxing, The Affiliated Hospital of Jiaxing University, Jiaxing, China.
- Department of Rheumatology, The First Hospital of Jiaxing, The Affiliated Hospital of Jiaxing University, Jiaxing, China.
- Department of Rheumatology, The First Hospital of Jiaxing, The Affiliated Hospital of Jiaxing University, Jiaxing, China. 00192649@zjxu.edu.cn
CER17756
2025 Vol.43, N°1
PI 0135, PF 0144
Reviews
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PMID: 39212131 [PubMed]
Received: 09/04/2024
Accepted : 24/06/2024
In Press: 20/08/2024
Published: 23/01/2025
Abstract
Left ventricular diastolic dysfunction (LVDD) plays a central role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF), a major manifestation of heart failure (HF). Low-grade inflammatory reaction is the key mechanism leading to LVDD. Rheumatoid arthritis (RA) is a systemic inflammatory disease and affects 0.5–1.0% of the adult population. Several epidemiologic studies find that the risk of LVDD is increased in RA than in the general population. Since inflammation plays an important role in the pathogenesis of LVDD and RA is a disease characterised by chronic systemic inflammation. RA may be involved in the occurrence and development of LVDD. This review summarises the pathogenesis, predictors, and management of LVDD in patients with RA.
