One year in review
Systemic sclerosis: one year in review 2024
G. Lepri1, M. Di Battista2, V. Codullo3, F. Bonomi4, A. Sulis5, S. Guiducci6, A. Della Rossa7
- Department of Experimental and Clinical Medicine, University of Florence, Section of Rheumatology, AOU Careggi, Florence, Italy.
- Rheumatology Unit, University of Pisa, Italy.
- Rheumatology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
- Department of Experimental and Clinical Medicine, University of Florence, Section of Rheumatology, AOU Careggi, Florence, Italy.
- Rheumatology Unit, University of Pisa, Italy.
- Department of Experimental and Clinical Medicine, University of Florence, Section of Rheumatology, AOU Careggi, Florence, Italy.
- Rheumatology Unit, University of Pisa, Italy. a.dellarossa@ao-pisa.toscana.it
CER17777
2024 Vol.42, N°8
PI 1517, PF 1528
One year in review
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PMID: 39058484 [PubMed]
Received: 15/04/2024
Accepted : 13/05/2024
In Press: 26/07/2024
Published: 13/08/2024
Abstract
Systemic sclerosis (SSc) is a rare and chronic connective tissue disease of unknown aetiology and characterised by three main pathogenetic events represented by endothelial damage, inflammation with activation of the immune system leading to production of specific autoantibodies and finally fibrosis. SSc is a heterogeneous disease and the classification in two subsets, the limited cutaneous (lcSSc) subset and the diffuse cutaneous one (dcSSc), is not capable of capturing the broad and different phenotypic expression of the disease. In the last years progress has been made in the knowledge of SSc pathogenesis, in its early diagnosis and new therapeutic strategies have been proposed, however, the management of SSc still represents a challenge for the clinician. For this reason, every year several studies investigate new insights of disease pathogenesis, internal organ involvement and therapeutic approaches. The purpose of this review is to provide an overview of the literature published in 2023.
